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Slc25a27 Gene Detail
Summary
  • Symbol
    Slc25a27
  • Name
    solute carrier family 25, member 27
  • Synonyms
    3632410G24Rik, 9430092A03Rik, D530043E16Rik, Ucp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921261
    NCBI Gene: 74011
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:43952782-43978105 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.75 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    955 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921261
 protein coding gene Chr17:43948630-43978105 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023778
 protein coding gene Chr17:44543352-44568888 (-)
A/J MGP_AJ_G0023736
 protein coding gene Chr17:43538108-43563523 (-)
AKR/J MGP_AKRJ_G0023707
 protein coding gene Chr17:43778549-43806596 (-)
BALB/cJ MGP_BALBcJ_G0023740
 protein coding gene Chr17:43429386-43454457 (-)
C3H/HeJ MGP_C3HHeJ_G0023504
 protein coding gene Chr17:44476456-44501942 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024183
 protein coding gene Chr17:46526594-46551799 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021633
 protein coding gene Chr17:40365080-40390493 (-)
CAST/EiJ MGP_CASTEiJ_G0022985
 protein coding gene Chr17:44513536-44540806 (-)
CBA/J MGP_CBAJ_G0023480
 protein coding gene Chr17:48162073-48189871 (-)
DBA/2J MGP_DBA2J_G0023606
 protein coding gene Chr17:42340101-42365345 (-)
FVB/NJ MGP_FVBNJ_G0023573
 protein coding gene Chr17:41902912-41928008 (-)
LP/J MGP_LPJ_G0023687
 protein coding gene Chr17:45207792-45234363 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023602
 protein coding gene Chr17:47809399-47835393 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024228
 protein coding gene Chr17:44129877-44156666 (-)
PWK/PhJ MGP_PWKPhJ_G0022730
 protein coding gene Chr17:41594181-41619998 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022545
 protein coding gene Chr17:40996732-41022379 (-)
WSB/EiJ MGP_WSBEiJ_G0023050
 protein coding gene Chr17:44654299-44679673 (-)



Homology
more
  • Human Ortholog
    SLC25A27, solute carrier family 25 member 27
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A27, solute carrier family 25 member 27
  • Synonyms
    UCP4
  • Links
    NCBI Gene ID: 9481
    neXtProt AC: NX_O95847
    UniProt: O95847

  • Chr Location
    6p12.3; chr6:46652915-46678190 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC25A27 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    864
  • Tissues
    80
  • cDNA Data
    13
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023912 Ensembl Gene Model | MGI Sequence Detail 25324 C57BL/6J ±  kb
transcript ENSMUST00000024705 Ensembl | MGI Sequence Detail 2895 Not Applicable  
polypeptide ENSMUSP00000024705 Ensembl | MGI Sequence Detail 322 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015023 mitochondrial uncoupling protein 4
    (term hierarchy)
  • InterPro Domains
    IPR023395 Mitochondrial carrier domain superfamily
    IPR050391 Mitochondrial Metabolite Transporter
    IPR018108 Mitochondrial substrate/solute carrier
  • GlyGen
    Q9D6D0 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 14
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:1925827, MGI:2442063
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:347870 Wang YY, et al., Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia. Mol Neurobiol. 2024 Feb;61(2):1119-1139
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory