Rap2b MGI Mouse Gene Detail - MGI:1921262 - RAP2B, member of RAS oncogene family

Symbol

Rap2b
Name

RAP2B, member of RAS oncogene family
Synonyms

4021402C18Rik

Feature Type

protein coding gene
IDs

MGI:1921262
NCBI Gene: 74012
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr3:61271928-61276124 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 29.81 cM
Mapping Data

2 experiments

SNPs within 2kb

118 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921262	protein coding gene	Chr3:61269059-61276124 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027256	protein coding gene	Chr3:60319736-60326517 (+)
A/J	MGP_AJ_G0027216	protein coding gene	Chr3:58552161-58558952 (+)
AKR/J	MGP_AKRJ_G0027186	protein coding gene	Chr3:59705585-59712376 (+)
BALB/cJ	MGP_BALBcJ_G0027229	protein coding gene	Chr3:58294871-58301652 (+)
C3H/HeJ	MGP_C3HHeJ_G0026972	protein coding gene	Chr3:59908985-59915770 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027675	protein coding gene	Chr3:62633172-62639954 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025029	protein coding gene	Chr3:55238287-55245044 (+)
CAST/EiJ	MGP_CASTEiJ_G0026424	protein coding gene	Chr3:60101964-60109496 (+)
CBA/J	MGP_CBAJ_G0026948	protein coding gene	Chr3:64638355-64645141 (+)
DBA/2J	MGP_DBA2J_G0027082	protein coding gene	Chr3:57946107-57952902 (+)
FVB/NJ	MGP_FVBNJ_G0027050	protein coding gene	Chr3:56839868-56846659 (+)
LP/J	MGP_LPJ_G0027193	protein coding gene	Chr3:61169815-61176597 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027067	protein coding gene	Chr3:68916518-68923427 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027733	protein coding gene	Chr3:59622363-59629147 (+)
PWK/PhJ	MGP_PWKPhJ_G0026156	protein coding gene	Chr3:57611461-57618384 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025969	protein coding gene	Chr3:59206086-59212864 (+)
WSB/EiJ	MGP_WSBEiJ_G0026498	protein coding gene	Chr3:59736974-59743801 (+)

Human Ortholog

RAP2B, RAP2B, member of RAS oncogene family

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAP2B, RAP2B, member of RAS oncogene family
Links

HGNC:9862

NCBI Gene ID: 5912

neXtProt AC: NX_P61225

UniProt: P61225
Chr Location

3q25.2; chr3:153162226-153170627 (+) GRCh38

MGI Vertebrate Homology

Rap2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAP2B
Gene Tree

Rap2b

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Rap2b
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

35
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

47
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rap2b

ZFIN rap2b

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All Sequences

45
RefSeq

2
UniProt

2
CCDS

CCDS17378.1

Ensembl

ENSMUSG00000036894 (Evidence)
NCBI Gene

74012

			Length	Strain/Species	Flank
genomic	74012	NCBI Gene Model \| MGI Sequence Detail	4197	C57BL/6J	± kb
transcript	NM_028712	RefSeq \| MGI Sequence Detail	4197	Not Specified
polypeptide	P61226	UniProt \| EBI \| MGI Sequence Detail	183	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013724 Ras-related protein Rap-2b

(term hierarchy)
EC

3.6.5.2
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR041840 Ras-related protein Rap2

IPR001806 Small GTPase

IPR020849 Small GTPase, Ras-type

IPR005225 Small GTP-binding protein domain
GlyGen

P61226 1 site, 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 15

Microarray probesets 9

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MGI:2139559

Summaries

All 39

Developmental Gene Expression 5

Diseases 1

Gene Ontology 6

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rap2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29333	Chr3:61271177-61271181 (+)	-749 bp
Tssr29334	Chr3:61271315-61271328 (+)	-606 bp
Tssr29335	Chr3:61271333-61271369 (+)	-577 bp
Tssr29336	Chr3:61271449-61271477 (+)	-465 bp
Tssr29337	Chr3:61271938-61271949 (+)	16 bp
Tssr29338	Chr3:61271976-61272054 (+)	87 bp
Tssr29339	Chr3:61272213-61272228 (+)	293 bp
Tssr29340	Chr3:61273424-61273445 (+)	1,507 bp
Tssr29341	Chr3:61273516-61273527 (+)	1,594 bp
Tssr29342	Chr3:61273799-61273816 (+)	1,880 bp
Tssr29343	Chr3:61273825-61273836 (+)	1,903 bp
Tssr29344	Chr3:61273938-61273943 (+)	2,013 bp
Tssr29345	Chr3:61274852-61274864 (+)	2,930 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24