Traf3ip1 MGI Mouse Gene Detail - MGI:1921269 - TRAF3 interacting protein 1

Symbol

Traf3ip1
Name

TRAF3 interacting protein 1
Synonyms

3930402D05Rik, MIP-T3

Feature Type

protein coding gene
IDs

MGI:1921269
NCBI Gene: 74019
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:91422369-91457029 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 46.16 cM
Mapping Data

2 experiments

SNPs within 2kb

925 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921269	protein coding gene	Chr1:91422311-91457029 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016311	protein coding gene	Chr1:93029897-93068105 (+)
A/J	MGP_AJ_G0016292	protein coding gene	Chr1:89685705-89721288 (+)
AKR/J	MGP_AKRJ_G0016253	protein coding gene	Chr1:92346107-92382169 (+)
BALB/cJ	MGP_BALBcJ_G0016248	protein coding gene	Chr1:89871115-89905752 (+)
C3H/HeJ	MGP_C3HHeJ_G0016077	protein coding gene	Chr1:92564745-92607839 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016707	protein coding gene	Chr1:96593991-96630006 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014425	protein coding gene	Chr1:83941123-83975769 (+)
CAST/EiJ	MGP_CASTEiJ_G0015662	protein coding gene	Chr1:91914227-91952174 (+)
CBA/J	MGP_CBAJ_G0016053	protein coding gene	Chr1:99694664-99729262 (+)
DBA/2J	MGP_DBA2J_G0016156	protein coding gene	Chr1:88912422-88946946 (+)
FVB/NJ	MGP_FVBNJ_G0016155	protein coding gene	Chr1:87947160-87984987 (+)
LP/J	MGP_LPJ_G0016227	protein coding gene	Chr1:94205070-94239480 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016180	protein coding gene	Chr1:102928694-102963337 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016747	protein coding gene	Chr1:92368203-92403432 (+)
PWK/PhJ	MGP_PWKPhJ_G0015446	protein coding gene	Chr1:88326503-88362278 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015229	protein coding gene	Chr1:91295916-91330399 (+)
WSB/EiJ	MGP_WSBEiJ_G0015720	protein coding gene	Chr1:92172151-92208606 (+)

Human Ortholog

TRAF3IP1, TRAF3 interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRAF3IP1, TRAF3 interacting protein 1
Synonyms

CFAP116, FAP116, IFT54, MIP-T3, MIPT3, SLSN9
Links

HGNC:17861

NCBI Gene ID: 26146

neXtProt AC: NX_Q8TDR0

UniProt: Q8TDR0
Chr Location

2q37.3; chr2:238320441-238400900 (+) GRCh38

MGI Vertebrate Homology

Traf3ip1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRAF3IP1
Gene Tree

Traf3ip1

Diseases

1 with human TRAF3IP1 associations

				Human Disease	Mouse Models
				Senior-Loken syndrome IDs Senior-Loken syndrome DOID:0050576 ICD10CM:Q61.5 MESH:C537580 OMIM:266900 OMIM:606995 OMIM:606996 OMIM:609254 OMIM:610189 OMIM:613615 OMIM:PS266900 ORDO:3156

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Traf3ip1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit embryonic lethality, cardiac edema, abnormal neural development, polydactyly, and microphthalmia associated with a lack of embryonic lethality.

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All GO Annotations

54
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

17
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase traf3ip1

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All Sequences

49
RefSeq

11
UniProt

2
CCDS

CCDS35664.1

Ensembl

ENSMUSG00000034292 (Evidence)
NCBI Gene

74019

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034292	Ensembl Gene Model \| MGI Sequence Detail	34661	C57BL/6J	± kb
transcript	ENSMUST00000189341	Ensembl \| MGI Sequence Detail	2257	Not Applicable
polypeptide	ENSMUSP00000140151	Ensembl \| MGI Sequence Detail	654	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016601 TRAF3-interacting protein 1

(term hierarchy)
PDB

5FMU
InterPro Domains

IPR018799 TRAF3-interacting protein 1

IPR041476 TRAF3-interacting protein 1, C-terminal domain

IPR040468 TRAF3-interacting protein 1, N-terminal

IPR042576 TRAF3-interacting protein 1, N-terminal domain superfamily

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All nucleic 11

cDNA 11

Microarray probesets 3

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MGI:2138493

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 13

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Traf3ip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8090	Chr1:91422318-91422346 (+)	-37 bp
Tssr8091	Chr1:91422353-91422420 (+)	18 bp
Tssr8092	Chr1:91422428-91422443 (+)	67 bp
Tssr8093	Chr1:91428524-91428581 (+)	6,184 bp
Tssr8094	Chr1:91455754-91455758 (+)	33,387 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24