Pex26 MGI Mouse Gene Detail - MGI:1921293 - peroxisomal biogenesis factor 26

Symbol

Pex26
Name

peroxisomal biogenesis factor 26
Synonyms

4632428M11Rik, peroxisome biogenesis factor 26

Feature Type

protein coding gene
IDs

MGI:1921293
NCBI Gene: 74043
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr6:121160626-121175796 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 57.13 cM
Mapping Data

2 experiments

SNPs within 2kb

427 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921293	protein coding gene	Chr6:121160176-121175796 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031213	protein coding gene	Chr6:124118750-124134610 (+)
A/J	MGP_AJ_G0031182	protein coding gene	Chr6:119337621-119352811 (+)
AKR/J	MGP_AKRJ_G0031113	protein coding gene	Chr6:122562016-122574405 (+)
BALB/cJ	MGP_BALBcJ_G0031193	protein coding gene	Chr6:119105238-119117660 (+)
C3H/HeJ	MGP_C3HHeJ_G0030911	protein coding gene	Chr6:122586767-122600998 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031651	protein coding gene	Chr6:127298535-127310913 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028811	protein coding gene	Chr6:116238511-116250600 (+)
CAST/EiJ	MGP_CASTEiJ_G0030300	protein coding gene	Chr6:123029304-123044447 (+)
CBA/J	MGP_CBAJ_G0030876	protein coding gene	Chr6:132351514-132364145 (+)
DBA/2J	MGP_DBA2J_G0031032	protein coding gene	Chr6:118229610-118242235 (+)
FVB/NJ	MGP_FVBNJ_G0030984	protein coding gene	Chr6:117373819-117389241 (+)
LP/J	MGP_LPJ_G0031111	protein coding gene	Chr6:124110379-124122749 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031018	protein coding gene	Chr6:136294096-136310333 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031680	protein coding gene	Chr6:122591844-122604227 (+)
PWK/PhJ	MGP_PWKPhJ_G0030015	protein coding gene	Chr6:117271032-117286259 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029844	protein coding gene	Chr6:121333422-121347123 (+)
WSB/EiJ	MGP_WSBEiJ_G0030383	protein coding gene	Chr6:122885243-122898389 (+)

Human Ortholog

PEX26, peroxisomal biogenesis factor 26

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PEX26, peroxisomal biogenesis factor 26
Synonyms

PBD7A, PBD7B, PEX26M1T, Pex26pM1T
Links

HGNC:22965

NCBI Gene ID: 55670

neXtProt AC: NX_Q7Z412

UniProt: Q7Z412
Chr Location

22q11.21; chr22:18077923-18105396 (+) GRCh38

MGI Vertebrate Homology

Pex26 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PEX26
Gene Tree

Pex26

Diseases

2 with human PEX26 associations

				Human Disease	Mouse Models
				peroxisome biogenesis disorder 7A IDs peroxisome biogenesis disorder 7A DOID:0080482 OMIM:614872
				Peroxisome biogenesis disorder 7B IDs Peroxisome biogenesis disorder 7B DOID:0081436 OMIM:614873

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

13
cDNA Data

43
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pex26

ZFIN pex26

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All Sequences

60
RefSeq

14
UniProt

3
CCDS

CCDS20488.1, CCDS80603.1, CCDS80604.1

Ensembl

ENSMUSG00000067825 (Evidence)
NCBI Gene

74043

			Length	Strain/Species	Flank
genomic	ENSMUSG00000067825	Ensembl Gene Model \| MGI Sequence Detail	15171	C57BL/6J	± kb
transcript	ENSMUST00000088561	Ensembl \| MGI Sequence Detail	4093	Not Applicable
polypeptide	ENSMUSP00000085921	Ensembl \| MGI Sequence Detail	305	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012563 peroxisome assembly protein 26

(term hierarchy)
InterPro Domains

IPR010797 Peroxisome assembly protein 26

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All nucleic 43

cDNA 43

Microarray probesets 3

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MGI:2141509

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pex26:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58563	Chr6:121160843-121160900 (+)	246 bp
Tssr58564	Chr6:121162415-121162430 (+)	1,797 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24