Siglecl2 Gene Detail

Summary

• Symbol
  Siglecl2
• Name
  Siglec family like 2
• Synonyms
  4930538L19Rik, 4931406B18Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1921304
  NCBI Gene: 74054
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr7:43141468-43155364 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 28.25 cM, cytoband B2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  563 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921304	protein coding gene	Chr7:43141468-43155393 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032129	protein coding gene	Chr7:43506627-43522352 (-)
A/J	MGP_AJ_G0032114	protein coding gene	Chr7:42619023-42632893 (-)
AKR/J	MGP_AKRJ_G0032044	protein coding gene	Chr7:43990801-44004519 (-)
BALB/cJ	MGP_BALBcJ_G0032119	protein coding gene	Chr7:42734029-42747932 (-)
C3H/HeJ	MGP_C3HHeJ_G0031835	protein coding gene	Chr7:44489323-44503186 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032603	protein coding gene	Chr7:45701154-45714920 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029626	protein coding gene	Chr7:44739888-44754302 (-)
CAST/EiJ	MGP_CASTEiJ_G0031165	protein coding gene	Chr7:35664139-35677981 (-)
CBA/J	MGP_CBAJ_G0031804	protein coding gene	Chr7:47151208-47166980 (-)
DBA/2J	MGP_DBA2J_G0031953	protein coding gene	Chr7:42419241-42433910 (-)
FVB/NJ	MGP_FVBNJ_G0031914	protein coding gene	Chr7:42138803-42152561 (-)
LP/J	MGP_LPJ_G0032032	protein coding gene	Chr7:44245552-44259464 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031950	protein coding gene	Chr7:46100950-46115139 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032623	protein coding gene	Chr7:43118379-43131999 (-)
PWK/PhJ	MGP_PWKPhJ_G0030886	protein coding gene	Chr7:35864518-35878956 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030725	protein coding gene	Chr7:31167357-31181111 (-)
WSB/EiJ	MGP_WSBEiJ_G0031279	protein coding gene	Chr7:43663228-43677168 (-)

Homology

• Human Ortholog
  SIGLEC1, sialic acid binding Ig like lectin 1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SIGLEC1, sialic acid binding Ig like lectin 1
  
• Synonyms
  CD169, SIGLEC-1, SN
• Links
  HGNC:11127

  NCBI Gene ID: 6614

  neXtProt AC: NX_Q9BZZ2

  UniProt: Q9BZZ2

  
  
• Chr Location
  20p13; chr20:3686970-3712600 (-)  GRCh38

---

• Human Ortholog
  SIGLECL1, SIGLEC family like 1
  
• Synonyms
  C19orf75, SIGLEC23P, SIGLECP7
• Links
  HGNC:26856

  NCBI Gene ID: 284369

  neXtProt AC: NX_Q8N7X8

  UniProt: Q8N7X8

  
  
• Chr Location
  19q13.41; chr19:51246332-51269330 (+)  GRCh38

---

• MGI Vertebrate Homology
  Siglecl2 stringent orthology
  2 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: SIGLEC1, SIGLECL1
• Gene Tree
  Siglecl2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  1
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  21 strains or lines available

Male mice homozygous for a mutation are viable and show normal fertility.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  4
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  7

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  51
• RefSeq
  4
• UniProt
  6
• CCDS
  CCDS21172.1

• Ensembl
  ENSMUSG00000013353 (Evidence)
• NCBI Gene
  74054

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000013353	Ensembl Gene Model | MGI Sequence Detail	13897	C57BL/6J
transcript	ENSMUST00000013497	Ensembl | MGI Sequence Detail	3970	Not Applicable
polypeptide	ENSMUSP00000013497	Ensembl | MGI Sequence Detail	367	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• InterPro Domains
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR051036 Sialic acid-binding Ig-like lectin

Molecular
Reagents

• All nucleic 7

  cDNA 7

  
  

  Microarray probesets 2

Other
Accession IDs

MGI:1922456, MGI:7595592

References

• Summaries
  All 20

  Gene Ontology 2

  Phenotypes 3
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:234235 Miyata H, et al., Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7704-10

TSS for Siglecl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72141	Chr7:43155350-43155368 (-)	5 bp