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Serpina3a Gene Detail
Summary
  • Symbol
    Serpina3a
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3A
  • Synonyms
    4933406L18Rik, alpha-1 antiproteinase,, antitrypsin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921319
    NCBI Gene: 74069
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr12:104078983-104088155 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 53.34 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    454 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921319
 protein coding gene Chr12:104078983-104088155 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020067
 protein coding gene Chr12:105870191-105879363 (+)
A/J MGP_AJ_G0020021
 protein coding gene Chr12:101878982-101888154 (+)
AKR/J MGP_AKRJ_G0019998
 protein coding gene Chr12:104724866-104748523 (+)
BALB/cJ MGP_BALBcJ_G0020007
 protein coding gene Chr12:102192063-102201179 (+)
C3H/HeJ MGP_C3HHeJ_G0019811
 protein coding gene Chr12:105245155-105254327 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020454
 protein coding gene Chr12:109184408-109193580 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018070
 protein coding gene Chr12:98554174-98568958 (+)
CAST/EiJ MGP_CASTEiJ_G0019351
 protein coding gene Chr12:100000088-100012213 (+)
CBA/J MGP_CBAJ_G0019777
 protein coding gene Chr12:113257608-113266724 (+)
DBA/2J MGP_DBA2J_G0019894
 protein coding gene Chr12:101313825-101322941 (+)
FVB/NJ MGP_FVBNJ_G0019880
 protein coding gene Chr12:100134634-100143818 (+)
LP/J MGP_LPJ_G0019969
 protein coding gene Chr12:105711607-105720779 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019918
 protein coding gene Chr12:116698999-116712509 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020482
 protein coding gene Chr12:104224381-104233553 (+)
PWK/PhJ MGP_PWKPhJ_G0019115
 protein coding gene Chr12:95859905-95869076 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018915
 protein coding gene Chr12:98428115-98434324 (+)
WSB/EiJ MGP_WSBEiJ_G0019410
 protein coding gene Chr12:105095011-105104309 (+)



Homology
more
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Synonyms
    AACT, ACT, GIG24, GIG25
  • Links
    NCBI Gene ID: 12
    neXtProt AC: NX_P01011
    UniProt: P01011

  • Chr Location
    14q32.13; chr14:94612384-94624055 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human SERPINA3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 74069 NCBI Gene Model | MGI Sequence Detail 9173 C57BL/6J ±  kb
transcript NM_001167705 RefSeq | MGI Sequence Detail 1864 C57BL/6  
polypeptide Q6P4P1 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:333149 Zhao T, et al., Sertoli cell PUMILIO proteins modulate mouse testis size through translational control of cell cycle regulators. Biol Reprod. 2022 Jul 25;107(1):135-147
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory