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Nmnat3 Gene Detail
Summary
  • Symbol
    Nmnat3
  • Name
    nicotinamide nucleotide adenylyltransferase 3
  • Synonyms
    4933408N02Rik, PNAT3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921330
    NCBI Gene: 74080
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98169488-98302491 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.35 cM, cytoband E4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3997 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921330
 protein coding gene Chr9:98169487-98302586 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035152
 protein coding gene Chr9:99584736-99721900 (+)
A/J MGP_AJ_G0035134
 protein coding gene Chr9:96086548-96218098 (+)
AKR/J MGP_AKRJ_G0035065
 protein coding gene Chr9:98425690-98563963 (+)
BALB/cJ MGP_BALBcJ_G0035126
 protein coding gene Chr9:95766940-95899013 (+)
C3H/HeJ MGP_C3HHeJ_G0034836
 protein coding gene Chr9:98832253-98962134 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035646
 protein coding gene Chr9:102420016-102563265 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032546
 protein coding gene Chr9:93860711-93990691 (+)
CAST/EiJ MGP_CASTEiJ_G0034148
 protein coding gene Chr9:98632627-98768467 (+)
CBA/J MGP_CBAJ_G0034804
 protein coding gene Chr9:105958203-106104270 (+)
DBA/2J MGP_DBA2J_G0034966
 protein coding gene Chr9:95601393-95732844 (+)
FVB/NJ MGP_FVBNJ_G0034914
 protein coding gene Chr9:94432285-94563922 (+)
LP/J MGP_LPJ_G0035045
 protein coding gene Chr9:99836306-99974070 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034953
 protein coding gene Chr9:107910120-108051310 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035668
 protein coding gene Chr9:98653893-98787272 (+)
PWK/PhJ MGP_PWKPhJ_G0033855
 protein coding gene Chr9:95802591-95934598 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033690
 protein coding gene Chr9:98713113-98848414 (+)
WSB/EiJ MGP_WSBEiJ_G0034268
 protein coding gene Chr9:98529307-98671820 (+)



Homology
more
  • Human Ortholog
    NMNAT3, nicotinamide nucleotide adenylyltransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NMNAT3, nicotinamide nucleotide adenylyltransferase 3
  • Synonyms
    FKSG76, PNAT-3, PNAT3
  • Links
    NCBI Gene ID: 349565
    neXtProt AC: NX_Q96T66
    UniProt: Q96T66

  • Chr Location
    3q23; chr3:139560180-139678050 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit splenomegaly and hemolytic anemia resulting from a glycolysis pathway blockade.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    99
  • cDNA Data
    18
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032456 Ensembl Gene Model | MGI Sequence Detail 133004 C57BL/6J ±  kb
    transcript ENSMUST00000112935 Ensembl | MGI Sequence Detail 2166 Not Applicable  
    polypeptide ENSMUSP00000108557 Ensembl | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011292 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
      (term hierarchy)
    • PDB
      5Z9R
    • EC
      2.7.7.1, 2.7.7.18
    • InterPro Domains
      IPR004821 Cytidyltransferase-like domain
      IPR051182 Eukaryotic NMN adenylyltransferase
      IPR045094 Nicotinamide/nicotinate mononucleotide adenylyltransferase, eukaryotic
      IPR005248 Nicotinate/nicotinamide nucleotide adenylyltransferase
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:331932 Mahmood A, et al., Nmnat3 deficiency in hemolytic anemia exacerbates malaria infection. Biochem Biophys Res Commun. 2022 Dec 31;637:58-65
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory