Rbm19 MGI Mouse Gene Detail - MGI:1921361 - RNA binding motif protein 19

Symbol

Rbm19
Name

RNA binding motif protein 19
Synonyms

1200009A02Rik

Feature Type

protein coding gene
IDs

MGI:1921361
NCBI Gene: 74111
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr5:120254578-120337036 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 60.58 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

1863 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921361	protein coding gene	Chr5:120254530-120337046 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030000	protein coding gene	Chr5:123429687-123517966 (+)
A/J	MGP_AJ_G0029964	protein coding gene	Chr5:118338505-118421107 (+)
AKR/J	MGP_AKRJ_G0029903	protein coding gene	Chr5:122170715-122253638 (+)
BALB/cJ	MGP_BALBcJ_G0029975	protein coding gene	Chr5:119764327-119847665 (+)
C3H/HeJ	MGP_C3HHeJ_G0029695	protein coding gene	Chr5:122703574-122789121 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030430	protein coding gene	Chr5:128076136-128161819 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027656	protein coding gene	Chr5:113069089-113152164 (+)
CAST/EiJ	MGP_CASTEiJ_G0029104	protein coding gene	Chr5:121794542-121882621 (+)
CBA/J	MGP_CBAJ_G0029663	protein coding gene	Chr5:133062688-133145162 (+)
DBA/2J	MGP_DBA2J_G0029813	protein coding gene	Chr5:118440675-118523909 (+)
FVB/NJ	MGP_FVBNJ_G0029769	protein coding gene	Chr5:117349431-117433206 (+)
LP/J	MGP_LPJ_G0029901	protein coding gene	Chr5:123905290-123992345 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029800	protein coding gene	Chr5:137066692-137150176 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030471	protein coding gene	Chr5:121735437-121820502 (+)
PWK/PhJ	MGP_PWKPhJ_G0028817	protein coding gene	Chr5:117186820-117270494 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028656	protein coding gene	Chr5:119383421-119478301 (+)
WSB/EiJ	MGP_WSBEiJ_G0029179	protein coding gene	Chr5:122323275-122408337 (+)

Human Ortholog

RBM19, RNA binding motif protein 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBM19, RNA binding motif protein 19
Synonyms

Mrd1
Links

HGNC:29098

NCBI Gene ID: 9904

neXtProt AC: NX_Q9Y4C8

UniProt: Q9Y4C8
Chr Location

12q24.13-q24.21; chr12:113816738-113966325 (-) GRCh38

MGI Vertebrate Homology

Rbm19 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RBM19
Gene Tree

Rbm19

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Gene trapped

12
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Rbm19
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available

Mice homozygous for a gene trap allele exhibit failure to undergo compaction, growth arrest at the morula stage, and apoptosis such that no embryos are observed at E6.5.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

34
cDNA Data

58
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rbm19

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All Sequences

50
RefSeq

2
UniProt

2
CCDS

CCDS19616.1

Ensembl

ENSMUSG00000029594 (Evidence)
NCBI Gene

74111

			Length	Strain/Species	Flank
genomic	74111	NCBI Gene Model \| MGI Sequence Detail	82459	C57BL/6J	± kb
transcript	NM_028762	RefSeq \| MGI Sequence Detail	4008	FVB/N
polypeptide	Q8R3C6	UniProt \| EBI \| MGI Sequence Detail	952	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031720 probable RNA-binding protein 19

(term hierarchy)
PDB

1WHW, 1WHX, 2CPF, 2CPH
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034418 Probable RNA-binding protein 19, RNA recognition motif 1

IPR034417 Probable RNA-binding protein 19, RNA recognition motif 2

IPR034419 Probable RNA-binding protein 19, RNA recognition motif 3

IPR034420 Probable RNA-binding protein 19, RNA recognition motif 4

IPR034423 Probable RNA-binding protein 19, RNA recognition motif 5

IPR034421 Probable RNA-binding protein 19, RNA recognition motif 6

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR003954 RNA recognition motif domain, eukaryote

IPR051945 RRM MRD1 RNA Processing and Ribosome Biogenesis
GlyGen

Q8R3C6 1 site, 1 O-linked glycan (1 site)

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All nucleic 59

cDNA 58

Primer pair 1

Microarray probesets 3

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MGI:2141122

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:293906 van Weerd JH, et al., Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction. Elife. 2020 Jul 16;9:e56697

TSS for Rbm19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48498	Chr5:120254545-120254590 (+)	-10 bp
Tssr48499	Chr5:120254591-120254616 (+)	26 bp
Tssr48500	Chr5:120283864-120283868 (+)	29,288 bp
Tssr48501	Chr5:120310881-120310896 (+)	56,311 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24