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Robo4 Gene Detail
Summary
  • Symbol
    Robo4
  • Name
    roundabout guidance receptor 4
  • Synonyms
    1200012D01Rik, Magic roundabout
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921394
    NCBI Gene: 74144
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:37313198-37325319 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921394
 protein coding gene Chr9:37313193-37326411 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034563
 protein coding gene Chr9:35377629-35389733 (+)
A/J MGP_AJ_G0034542
 protein coding gene Chr9:34441213-34453370 (+)
AKR/J MGP_AKRJ_G0034469
 protein coding gene Chr9:35204140-35216260 (+)
BALB/cJ MGP_BALBcJ_G0034533
 protein coding gene Chr9:34286110-34298228 (+)
C3H/HeJ MGP_C3HHeJ_G0034246
 protein coding gene Chr9:35636436-35648556 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035055
 protein coding gene Chr9:36506718-36518842 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031981
 protein coding gene Chr9:33557867-33569809 (+)
CAST/EiJ MGP_CASTEiJ_G0033567
 protein coding gene Chr9:35328123-35340217 (+)
CBA/J MGP_CBAJ_G0034219
 protein coding gene Chr9:37772408-37784509 (+)
DBA/2J MGP_DBA2J_G0034377
 protein coding gene Chr9:34497998-34510104 (+)
FVB/NJ MGP_FVBNJ_G0034318
 protein coding gene Chr9:33740984-33753094 (+)
LP/J MGP_LPJ_G0034462
 protein coding gene Chr9:35578271-35590661 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034364
 protein coding gene Chr9:39387902-39400009 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035074
 protein coding gene Chr9:35139121-35152111 (+)
PWK/PhJ MGP_PWKPhJ_G0033273
 protein coding gene Chr9:34393434-34406112 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033107
 protein coding gene Chr9:35341374-35353203 (+)
WSB/EiJ MGP_WSBEiJ_G0033683
 protein coding gene Chr9:34945825-34957929 (+)



Homology
more
  • Human Ortholog
    ROBO4, roundabout guidance receptor 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROBO4, roundabout guidance receptor 4
  • Synonyms
    AOVD3, ECSM4, MRB
  • Links
    NCBI Gene ID: 54538
    neXtProt AC: NX_Q8WZ75
    UniProt: Q8WZ75

  • Chr Location
    11q24.2; chr11:124883691-124898500 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ROBO4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization. Homozygous KO also improves glucose metabolism and adipose tissue angiogenesis when fed high-fat diet and increases exercise endurance on normal chow.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    39
  • cDNA Data
    32
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74144 NCBI Gene Model | MGI Sequence Detail 12122 C57BL/6J ±  kb
    transcript NM_001309390 RefSeq | MGI Sequence Detail 3785 C57BL/6  
    polypeptide Q8C310 UniProt | EBI | MGI Sequence Detail 1012 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 33

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143097
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 20
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:358325 Deng F, et al., CircSlc17a5 controlled by VLDLR/QKI pathway regulated the choroidal angiogenesis. Biochim Biophys Acta Mol Cell Res. 2024 Jul 26;1871(7):119802
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory