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Errfi1 Gene Detail
Summary
  • Symbol
    Errfi1
  • Name
    ERBB receptor feedback inhibitor 1
  • Synonyms
    1300002F13Rik, Mig-6, RALT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921405
    NCBI Gene: 74155
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:150938376-150953349 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 81.50 cM, cytoband E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921405
 protein coding gene Chr4:150938253-150953349 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029156
 protein coding gene Chr4:154879012-154893766 (+)
A/J MGP_AJ_G0029121
 protein coding gene Chr4:148358183-148373142 (+)
AKR/J MGP_AKRJ_G0029069
 protein coding gene Chr4:152422398-152437370 (+)
BALB/cJ MGP_BALBcJ_G0029137
 protein coding gene Chr4:148848790-148863936 (+)
C3H/HeJ MGP_C3HHeJ_G0028858
 protein coding gene Chr4:152990363-153005340 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029586
 protein coding gene Chr4:160436249-160452933 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026832
 protein coding gene Chr4:140751980-140766907 (+)
CAST/EiJ MGP_CASTEiJ_G0028271
 protein coding gene Chr4:150268161-150283049 (+)
CBA/J MGP_CBAJ_G0028820
 protein coding gene Chr4:165189637-165206240 (+)
DBA/2J MGP_DBA2J_G0028969
 protein coding gene Chr4:148435273-148450185 (+)
FVB/NJ MGP_FVBNJ_G0028933
 protein coding gene Chr4:147587033-147602536 (+)
LP/J MGP_LPJ_G0029059
 protein coding gene Chr4:154799429-154814351 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028960
 protein coding gene Chr4:168311277-168335896 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029618
 protein coding gene Chr4:152950006-152964950 (+)
PWK/PhJ MGP_PWKPhJ_G0027991
 protein coding gene Chr4:144474578-144489537 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027825
 protein coding gene Chr4:147193577-147208331 (+)
WSB/EiJ MGP_WSBEiJ_G0028351
 protein coding gene Chr4:153087096-153103161 (+)



Homology
more
  • Human Ortholog
    ERRFI1, ERBB receptor feedback inhibitor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERRFI1, ERBB receptor feedback inhibitor 1
  • Synonyms
    GENE-33, MIG-6, MIG6, RALT
  • Links
    NCBI Gene ID: 54206
    neXtProt AC: NX_Q9UJM3
    UniProt: Q9UJM3

  • Chr Location
    1p36.23; chr1:8004404-8026309 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Errfi1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 5 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    11 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene may lead to premature death, delayed eyelid opening, epidermal hyperplasia, degenerative joint disease, skin or lung cancer, gastrointestinal tract tumors, increased susceptibility to chemically-induced tumors, and impaired lung development and vascularization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    14
  • cDNA Data
    218
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028967 Ensembl Gene Model | MGI Sequence Detail 14974 C57BL/6J ±  kb
    transcript ENSMUST00000073600 Ensembl | MGI Sequence Detail 3036 Not Applicable  
    polypeptide ENSMUSP00000073285 Ensembl | MGI Sequence Detail 461 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 219
      cDNA 218
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140358
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 4
      Diseases 3
      Gene Ontology 26
      Phenotypes 35
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:311128 Choung S, et al., Mig-6 is essential for glucose homeostasis and thermogenesis in brown adipose tissue. Biochem Biophys Res Commun. 2021 Oct 1;572:92-97
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory