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Gtsf1 Gene Detail
Summary
  • Symbol
    Gtsf1
  • Name
    gametocyte specific factor 1
  • Synonyms
    1700006H03Rik, Cue110
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921424
    NCBI Gene: 74174
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103310885-103338872 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 58.93 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    370 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921424
 protein coding gene Chr15:103310832-103338897 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022441
 protein coding gene Chr15:105676245-105697726 (-)
A/J MGP_AJ_G0022403
 protein coding gene Chr15:101490998-101509423 (-)
AKR/J MGP_AKRJ_G0022378
 protein coding gene Chr15:104571187-104591843 (-)
BALB/cJ MGP_BALBcJ_G0022407
 protein coding gene Chr15:101537752-101556931 (-)
C3H/HeJ MGP_C3HHeJ_G0022174
 protein coding gene Chr15:104672735-104691619 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022856
 protein coding gene Chr15:109578524-109598800 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020379
 protein coding gene Chr15:97247862-97267023 (-)
CAST/EiJ MGP_CASTEiJ_G0021700
 protein coding gene Chr15:105533123-105552373 (-)
CBA/J MGP_CBAJ_G0022143
 protein coding gene Chr15:113415734-113441562 (-)
DBA/2J MGP_DBA2J_G0022274
 protein coding gene Chr15:100764898-100785544 (-)
FVB/NJ MGP_FVBNJ_G0022250
 protein coding gene Chr15:99821440-99839659 (-)
LP/J MGP_LPJ_G0022343
 protein coding gene Chr15:105821381-105844275 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022272
 protein coding gene Chr15:116906688-116928307 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022868
 protein coding gene Chr15:104605144-104625299 (-)
PWK/PhJ MGP_PWKPhJ_G0021440
 protein coding gene Chr15:100943801-100964385 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021272
 protein coding gene Chr15:104442130-104466128 (-)
WSB/EiJ MGP_WSBEiJ_G0021750
 protein coding gene Chr15:105230023-105250086 (-)



Homology
more
  • Human Ortholog
    GTSF1, gametocyte specific factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTSF1, gametocyte specific factor 1
  • Synonyms
    Cue110, FAM112B
  • Links
    NCBI Gene ID: 121355
    neXtProt AC: NX_Q8WW33
    UniProt: Q8WW33

  • Chr Location
    12q13.13; chr12:54455950-54473602 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility due to arrested male meiosis and apoptosis of male germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    50
  • cDNA Data
    38
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74174 NCBI Gene Model | MGI Sequence Detail 27988 C57BL/6J ±  kb
    transcript NM_028797 RefSeq | MGI Sequence Detail 740 C57BL/6  
    polypeptide Q9DAN6 UniProt | EBI | MGI Sequence Detail 167 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 38
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:341525 Arif A, et al., GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins. Nature. 2022 Aug;608(7923):618-625
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory