Muc5b Gene Detail

Summary

• Symbol
  Muc5b
• Name
  mucin 5, subtype B, tracheobronchial
• Synonyms
  2300002I04Rik, MUC5, MUC9

• Feature Type
  protein coding gene
• IDs
  MGI:1921430
  NCBI Gene: 74180
• Alliance
  gene page
• Transcription Start Sites
  35 TSS

Location &
Maps

• Sequence Map
  Chr7:141392807-141426821 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 87.29 cM, cytoband F5
• Mapping Data
  5 experiments

Strain
Comparison

• SNPs within 2kb
  672 from dbSNP Build 142
• Strain Annotations
  13

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921430	protein coding gene	Chr7:141392796-141426826 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	MGP_AKRJ_G0033156	protein coding gene	Chr7:146783476-146831888 (+)
BALB/cJ	MGP_BALBcJ_G0033224	protein coding gene	Chr7:142545085-142585343 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0033736	protein coding gene	Chr7:152391275-152428653 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030709	protein coding gene	Chr7:144011344-144044701 (+)
CAST/EiJ	MGP_CASTEiJ_G0032269	protein coding gene	Chr7:138841867-138879674 (+)
CBA/J	MGP_CBAJ_G0032911	protein coding gene	Chr7:157550764-157595295 (+)
DBA/2J	MGP_DBA2J_G0033063	protein coding gene	Chr7:140756373-140788514 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0033158	protein coding gene	Chr7:148515091-148553974 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033049	protein coding gene	Chr7:158184555-158228070 (+)
NZO/HlLtJ	no annotation
PWK/PhJ	MGP_PWKPhJ_G0031973	protein coding gene	Chr7:134048985-134086050 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031819	protein coding gene	Chr7:132567454-132598911 (+)
WSB/EiJ	MGP_WSBEiJ_G0032379	protein coding gene	Chr7:146729192-146739140 (+)

Homology

• Human Ortholog
  MUC5B, mucin 5B, oligomeric mucus/gel-forming

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MUC5B, mucin 5B, oligomeric mucus/gel-forming
  
• Synonyms
  MG1, MUC5, MUC-5B, MUC9
• Links
  HGNC:7516

  NCBI Gene ID: 727897

  neXtProt AC: NX_Q9HC84

  UniProt: Q9HC84

  
  
• Chr Location
  11p15.5

---

• MGI Vertebrate Homology
  Muc5b stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: MUC5B
• Gene Tree
  Muc5b
  

Human Diseases

• Diseases
  4 with human MUC5B associations

				Human Disease	Mouse Models
				bronchiolitis IDs bronchiolitis       DOID:2942 MESH:D001988 NCI:C39658 UMLS_CUI:C0006271
				idiopathic pulmonary fibrosis IDs idiopathic pulmonary fibrosis       DOID:0050156 EFO:0000768 ICD10CM:J84.112 ICD9CM:516.31 MESH:D054990 NCI:C35716 UMLS_CUI:C1800706
				interstitial lung disease 2 IDs interstitial lung disease 2       DOID:0060971 OMIM:178500
				urinary bladder cancer IDs urinary bladder cancer       DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  24 phenotypes from 3 alleles in 3 genetic backgrounds
  25 phenotype references
  

• All Mutations and Alleles
  15
• Endonuclease-mediated
  5
• Gene trapped
  1
• Radiation induced
  1
• Targeted
  7
• Transgenic
  1
• Genomic Mutations
  1 involving Muc5b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  215 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele accumulate materials in the upper and lower airways leading to chronic infection and inflammation that does not resolve and results in premature death. Macrophage function is impaired.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  6
• GO References
  4

Expression

• Assay Results
  739
• Tissues
  13
• cDNA Data
  6
• Literature Summary
  7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  35
• RefSeq
  4
• UniProt
  5
• CCDS
  CCDS52448.1

• Ensembl
  ENSMUSG00000066108 (Evidence)
• NCBI Gene
  74180

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000066108	Ensembl Gene Model | MGI Sequence Detail	34015	C57BL/6J
transcript	ENSMUST00000165147	Ensembl | MGI Sequence Detail	14964	Not Applicable
polypeptide	ENSMUSP00000128276	Ensembl | MGI Sequence Detail	4800	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• InterPro Domains
  IPR006207 Cystine knot, C-terminal
  IPR029034 Cystine-knot cytokine
  IPR006208 Glycoprotein hormone subunit beta
  IPR050780 Mucin/von Willebrand/Thrombospondin superfamily
  IPR036084 Serine protease inhibitor-like superfamily
  IPR002919 Trypsin Inhibitor-like, cysteine rich domain
  IPR001846 von Willebrand factor, type D domain
  IPR001007 VWFC domain
  IPR014853 VWF/SSPO/Zonadhesin-like, cysteine-rich domain
  IPR025155 WxxW domain
• GlyGen
  E9Q5I3 7 sites, 4 N-linked glycans (7 sites)

Molecular
Reagents

• All nucleic 7

  cDNA 6

  Primer pair 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2142176

References

• Summaries
  All 66

  Developmental Gene Expression 7

  Gene Ontology 4

  Phenotypes 25
• Earliest
  J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Muc5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70077	Chr7:141392802-141392819 (+)	4 bp
Tssr70078	Chr7:141398480-141398525 (+)	5,696 bp
Tssr70079	Chr7:141399097-141399107 (+)	6,295 bp
Tssr70080	Chr7:141399109-141399114 (+)	6,305 bp
Tssr70081	Chr7:141410436-141410447 (+)	17,635 bp
Tssr70082	Chr7:141410521-141410532 (+)	17,720 bp
Tssr70083	Chr7:141411260-141411269 (+)	18,458 bp
Tssr70084	Chr7:141411384-141411396 (+)	18,583 bp
Tssr70085	Chr7:141411588-141411604 (+)	18,789 bp
Tssr70086	Chr7:141412083-141412127 (+)	19,298 bp
Tssr70087	Chr7:141412588-141412628 (+)	19,801 bp
Tssr70088	Chr7:141412881-141412891 (+)	20,079 bp
Tssr70089	Chr7:141414859-141414862 (+)	22,054 bp
Tssr70090	Chr7:141415098-141415102 (+)	22,293 bp
Tssr70091	Chr7:141415288-141415298 (+)	22,486 bp
Tssr70092	Chr7:141415303-141415313 (+)	22,501 bp
Tssr70093	Chr7:141415413-141415424 (+)	22,612 bp
Tssr70094	Chr7:141415448-141415455 (+)	22,645 bp
Tssr70095	Chr7:141415502-141415505 (+)	22,697 bp
Tssr70096	Chr7:141415586-141415608 (+)	22,790 bp
Tssr70097	Chr7:141415720-141415726 (+)	22,916 bp
Tssr70098	Chr7:141415728-141415737 (+)	22,926 bp
Tssr70099	Chr7:141415747-141415752 (+)	22,943 bp
Tssr70100	Chr7:141415795-141415800 (+)	22,991 bp
Tssr70101	Chr7:141416710-141416724 (+)	23,910 bp
Tssr70102	Chr7:141417479-141417493 (+)	24,679 bp
Tssr70103	Chr7:141417898-141417903 (+)	25,094 bp
Tssr70104	Chr7:141418090-141418131 (+)	25,304 bp
Tssr70105	Chr7:141418321-141418332 (+)	25,520 bp
Tssr70106	Chr7:141418396-141418406 (+)	25,594 bp
Tssr70107	Chr7:141418436-141418446 (+)	25,634 bp
Tssr70108	Chr7:141418610-141418620 (+)	25,808 bp
Tssr70109	Chr7:141418713-141418721 (+)	25,910 bp
Tssr70110	Chr7:141418748-141418753 (+)	25,944 bp
Tssr70111	Chr7:141420508-141420514 (+)	27,704 bp