Vit MGI Mouse Gene Detail - MGI:1921449

Symbol

Vit
Name

vitrin
Synonyms

1700052E02Rik, 1700110E08Rik, 2810429K11Rik, AKH, akhirin

Feature Type

protein coding gene
IDs

MGI:1921449
NCBI Gene: 74199
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr17:78815493-78934837 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 49.38 cM, cytoband E3
Mapping Data

3 experiments

SNPs within 2kb

4160 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921449	protein coding gene	Chr17:78815480-78934838 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024038	protein coding gene	Chr17:81325674-81454428 (+)
A/J	MGP_AJ_G0023995	protein coding gene	Chr17:78867097-78959255 (+)
AKR/J	MGP_AKRJ_G0023964	protein coding gene	Chr17:80058128-80155188 (+)
BALB/cJ	MGP_BALBcJ_G0023997	protein coding gene	Chr17:78723066-78818305 (+)
C3H/HeJ	MGP_C3HHeJ_G0023761	protein coding gene	Chr17:80960026-81056577 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024442	protein coding gene	Chr17:84285823-84425218 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0023241	protein coding gene	Chr17:81519651-81648824 (+)
CBA/J	MGP_CBAJ_G0023735	protein coding gene	Chr17:87853598-87963954 (+)
DBA/2J	MGP_DBA2J_G0023864	protein coding gene	Chr17:77385082-77480071 (+)
FVB/NJ	MGP_FVBNJ_G0023830	protein coding gene	Chr17:76906003-77000161 (+)
LP/J	MGP_LPJ_G0023947	protein coding gene	Chr17:82175069-82298246 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023858	protein coding gene	Chr17:87967595-88067540 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024486	protein coding gene	Chr17:80487380-80631864 (+)
PWK/PhJ	MGP_PWKPhJ_G0022987	protein coding gene	Chr17:76841946-76989313 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022798	protein coding gene	Chr17:77287006-77420999 (+)
WSB/EiJ	MGP_WSBEiJ_G0023308	protein coding gene	Chr17:81313509-81449649 (+)

Human Ortholog

VIT, vitrin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VIT, vitrin
Synonyms

VIT1
Links

HGNC:12697

NCBI Gene ID: 5212

neXtProt AC: NX_Q6UXI7

UniProt: Q6UXI7
Chr Location

2p22.2; chr2:36696690-36814794 (+) GRCh38

MGI Vertebrate Homology

Vit stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VIT
Gene Tree

Vit

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a knock-out allele show decreased spinal cord size associated with reduced cell proliferation and altered cell differentiation in the central canal.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

905
Tissues

19
cDNA Data

24
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA VIT

Xenbase vit

ZFIN vit

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All Sequences

44
RefSeq

8
UniProt

2
CCDS

CCDS37696.1, CCDS89157.1

Ensembl

ENSMUSG00000024076 (Evidence)
NCBI Gene

74199

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024076	Ensembl Gene Model \| MGI Sequence Detail	119345	C57BL/6J	± kb
transcript	ENSMUST00000024880	Ensembl \| MGI Sequence Detail	2708	Not Applicable
polypeptide	ENSMUSP00000024880	Ensembl \| MGI Sequence Detail	650	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017302 vitrin

(term hierarchy)
InterPro Domains

IPR050525 Extracellular Matrix Assembly and Organization

IPR004043 LCCL domain

IPR036609 LCCL domain superfamily

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A
GlyGen

Q8VHI5 1 site, 1 N-linked glycan (1 site)

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All nucleic 26

cDNA 26

Microarray probesets 3

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MGI:1920620, MGI:1925724

Summaries

All 37

Developmental Gene Expression 8

Gene Ontology 4

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Vit:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145896	Chr17:78815543-78815562 (+)	60 bp
Tssr145897	Chr17:78815565-78815593 (+)	86 bp
Tssr145898	Chr17:78815639-78815646 (+)	150 bp
Tssr145899	Chr17:78868422-78868466 (+)	52,951 bp
Tssr145900	Chr17:78881300-78881311 (+)	65,813 bp
Tssr145901	Chr17:78881313-78881320 (+)	65,824 bp
Tssr145902	Chr17:78881326-78881349 (+)	65,845 bp
Tssr145903	Chr17:78881354-78881369 (+)	65,869 bp
Tssr145904	Chr17:78881372-78881375 (+)	65,881 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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