Sipa1l3 MGI Mouse Gene Detail - MGI:1921456 - signal-induced proliferation-associated 1 like 3

Symbol

Sipa1l3
Name

signal-induced proliferation-associated 1 like 3
Synonyms

2610511M17Rik

Feature Type

protein coding gene
IDs

MGI:1921456
NCBI Gene: 74206
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr7:29019797-29218066 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.94 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

6089 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921456	protein coding gene	Chr7:29016687-29218694 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031983	protein coding gene	Chr7:28244997-28448766 (-)
A/J	MGP_AJ_G0031961	protein coding gene	Chr7:27493822-27694774 (-)
AKR/J	MGP_AKRJ_G0031894	protein coding gene	Chr7:28213771-28424981 (-)
BALB/cJ	MGP_BALBcJ_G0031968	protein coding gene	Chr7:27693063-27891997 (-)
C3H/HeJ	MGP_C3HHeJ_G0031687	protein coding gene	Chr7:28612040-28823208 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032433	protein coding gene	Chr7:29142199-29356484 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029483	protein coding gene	Chr7:28547200-28745647 (-)
CAST/EiJ	MGP_CASTEiJ_G0031021	protein coding gene	Chr7:21879669-22093554 (-)
CBA/J	MGP_CBAJ_G0031653	protein coding gene	Chr7:30514094-30736104 (-)
DBA/2J	MGP_DBA2J_G0031805	protein coding gene	Chr7:27234768-27433398 (-)
FVB/NJ	MGP_FVBNJ_G0031762	protein coding gene	Chr7:27352520-27556297 (-)
LP/J	MGP_LPJ_G0031885	protein coding gene	Chr7:28544222-28753588 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031797	protein coding gene	Chr7:29877930-30081026 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032462	protein coding gene	Chr7:27700837-27908267 (-)
PWK/PhJ	MGP_PWKPhJ_G0030747	protein coding gene	Chr7:22292158-22495328 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030580	protein coding gene	Chr7:18710525-18924010 (-)
WSB/EiJ	MGP_WSBEiJ_G0031131	protein coding gene	Chr7:28079838-28290682 (-)

Human Ortholog

SIPA1L3, signal induced proliferation associated 1 like 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SIPA1L3, signal induced proliferation associated 1 like 3
Synonyms

CTRCT45, SPAL3, SPAR3
Links

HGNC:23801

NCBI Gene ID: 23094

neXtProt AC: NX_O60292

UniProt: O60292
Chr Location

19q13.13-q13.2; chr19:37907208-38208369 (+) GRCh38

MGI Vertebrate Homology

Sipa1l3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SIPA1L3
Gene Tree

Sipa1l3

Diseases

1 with human SIPA1L3 associations

				Human Disease	Mouse Models
				cataract 45 IDs cataract 45 DOID:0110262 ICD10CM:Q12.0 OMIM:616851

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

423
Endonuclease-mediated

1
Gene trapped

422
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

363 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit small lenses, microphthalmia, cataracts, posterior iris synechia, and abnormal lens fiber morphology.

less

All GO Annotations

31
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

9
cDNA Data

18
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sipa1l3

ZFIN sipa1l3

less

All Sequences

111
RefSeq

32
UniProt

15
CCDS

CCDS39871.1

Ensembl

ENSMUSG00000030583 (Evidence)
NCBI Gene

74206

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030583	Ensembl Gene Model \| MGI Sequence Detail	198270	C57BL/6J	± kb
transcript	ENSMUST00000085809	Ensembl \| MGI Sequence Detail	7713	Not Applicable
polypeptide	ENSMUSP00000082965	Ensembl \| MGI Sequence Detail	1776	Not Applicable

less

UniProt

15 Sequences
Protein Ontology

PR:000014883 signal-induced proliferation-associated 1-like protein 3

(term hierarchy)
InterPro Domains

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR050989 Rap1/Ran GTPase-activating

IPR000331 Rap/Ran-GAP domain

IPR035974 Rap/Ran-GAP superfamily

IPR021818 Signal-induced proliferation-associated 1-like protein, C-terminal
GlyGen

G3X9J0 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)

less

All nucleic 20

cDNA 18

Primer pair 1

Other 1

Microarray probesets 4

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 10
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:254716 Walker LR, et al., A 16.7 kb deletion in Sipa1l3 is associated with juvenile cataract in mice. Mamm Genome. 2017 Dec;28(11-12):515-519

TSS for Sipa1l3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr71670	Chr7:29217991-29218045 (-)	48 bp
Tssr71669	Chr7:29217967-29217990 (-)	87 bp
Tssr71668	Chr7:29217961-29217966 (-)	102 bp
Tssr71667	Chr7:29205339-29205342 (-)	12,725 bp
Tssr71666	Chr7:29205217-29205247 (-)	12,834 bp
Tssr71665	Chr7:29205200-29205215 (-)	12,858 bp
Tssr71664	Chr7:29205179-29205190 (-)	12,881 bp
Tssr71663	Chr7:29205153-29205173 (-)	12,903 bp
Tssr71662	Chr7:29204988-29205004 (-)	13,070 bp
Tssr71661	Chr7:29204872-29204898 (-)	13,181 bp
Tssr71660	Chr7:29204758-29204870 (-)	13,252 bp
Tssr71659	Chr7:29181039-29181046 (-)	37,023 bp
Tssr71658	Chr7:29142975-29142977 (-)	75,090 bp
Tssr71657	Chr7:29097103-29097134 (-)	120,947 bp
Tssr71656	Chr7:29053731-29053763 (-)	164,319 bp
Tssr71655	Chr7:29053707-29053724 (-)	164,350 bp
Tssr71654	Chr7:29044325-29044341 (-)	173,733 bp
Tssr71653	Chr7:29044269-29044285 (-)	173,789 bp
Tssr71652	Chr7:29038641-29038677 (-)	179,407 bp
Tssr71651	Chr7:29038613-29038628 (-)	179,445 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24