Dnal1 MGI Mouse Gene Detail - MGI:1921462 - dynein, axonemal, light chain 1

Symbol

Dnal1
Name

dynein, axonemal, light chain 1
Synonyms

1700010H15Rik, Dnal1, Dnalc1, E330027P08Rik

Feature Type

protein coding gene
IDs

MGI:1921462
NCBI Gene: 105000
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:84161057-84190291 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.05 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

930 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921462	protein coding gene	Chr12:84161057-84194272 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019928	protein coding gene	Chr12:84796924-84831070 (+)
A/J	MGP_AJ_G0019885	protein coding gene	Chr12:81591776-81624901 (+)
AKR/J	MGP_AKRJ_G0019861	protein coding gene	Chr12:83798077-83834328 (+)
BALB/cJ	MGP_BALBcJ_G0019865	protein coding gene	Chr12:81922089-81956337 (+)
C3H/HeJ	MGP_C3HHeJ_G0019671	protein coding gene	Chr12:84274725-84309639 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020316	protein coding gene	Chr12:87240571-87273431 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017934	protein coding gene	Chr12:78500634-78535645 (+)
CAST/EiJ	MGP_CASTEiJ_G0019220	protein coding gene	Chr12:79208943-79245399 (+)
CBA/J	MGP_CBAJ_G0019642	protein coding gene	Chr12:90605274-90640877 (+)
DBA/2J	MGP_DBA2J_G0019757	protein coding gene	Chr12:81123209-81156747 (+)
FVB/NJ	MGP_FVBNJ_G0019743	protein coding gene	Chr12:80078963-80112444 (+)
LP/J	MGP_LPJ_G0019829	protein coding gene	Chr12:84678431-84716062 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019782	protein coding gene	Chr12:93542206-93575227 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020350	protein coding gene	Chr12:83401752-83435001 (+)
PWK/PhJ	MGP_PWKPhJ_G0018984	protein coding gene	Chr12:75608144-75641754 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018779	protein coding gene	Chr12:77876990-77912495 (+)
WSB/EiJ	MGP_WSBEiJ_G0019272	protein coding gene	Chr12:84066449-84103010 (+)

Human Ortholog

DNAL1, dynein axonemal light chain 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAL1, dynein axonemal light chain 1
Synonyms

C14orf168, CILD16, LC1
Links

HGNC:23247

NCBI Gene ID: 83544

neXtProt AC: NX_Q4LDG9

UniProt: Q4LDG9
Chr Location

14q24.3; chr14:73644875-73703732 (+) GRCh38

MGI Vertebrate Homology

Dnal1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAL1
Gene Tree

Dnal1

Diseases

1 with human DNAL1 associations

				Human Disease	Mouse Models
				primary ciliary dyskinesia 16 IDs primary ciliary dyskinesia 16 DOID:0110613 ICD10CM:Q34.8 OMIM:614017

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Dnal1
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

3
cDNA Data

9
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnal1

ZFIN dnal1

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All Sequences

54
RefSeq

6
UniProt

4
CCDS

CCDS26039.2, CCDS83987.1

Ensembl

ENSMUSG00000042523 (Evidence)
NCBI Gene

105000

			Length	Strain/Species	Flank
genomic	105000	NCBI Gene Model \| MGI Sequence Detail	29235	C57BL/6J	± kb
transcript	NM_001346528	RefSeq \| MGI Sequence Detail	5893	C57BL/6
polypeptide	Q05A62	UniProt \| EBI \| MGI Sequence Detail	190	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006589 dynein axonemal light chain 1

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR025875 Leucine rich repeat 4

IPR032675 Leucine-rich repeat domain superfamily

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All nucleic 9

cDNA 9

Microarray probesets 6

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MGI:2145006

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnal1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114319	Chr12:84161073-84161084 (+)	22 bp
Tssr114320	Chr12:84161095-84161157 (+)	69 bp
Tssr114321	Chr12:84173015-84173020 (+)	11,961 bp
Tssr114322	Chr12:84179310-84179331 (+)	18,264 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24