Liat1 MGI Mouse Gene Detail - MGI:1921480

Symbol

Liat1
Name

ligand of ATE1
Synonyms

1700016K19Rik

Feature Type

protein coding gene
IDs

MGI:1921480
NCBI Gene: 74230
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:75890738-75894395 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.92 cM
Mapping Data

1 experiment

SNPs within 2kb

229 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921480	protein coding gene	Chr11:75890738-75894395 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018725	protein coding gene	Chr11:76794880-76798537 (+)
A/J	MGP_AJ_G0018691	protein coding gene	Chr11:73927377-73931034 (+)
AKR/J	MGP_AKRJ_G0018661	protein coding gene	Chr11:76165901-76169558 (+)
BALB/cJ	MGP_BALBcJ_G0018665	protein coding gene	Chr11:74306886-74310543 (+)
C3H/HeJ	MGP_C3HHeJ_G0018478	protein coding gene	Chr11:76185161-76188820 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019116	protein coding gene	Chr11:79209538-79213195 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016751	protein coding gene	Chr11:70941839-70945557 (+)
CAST/EiJ	MGP_CASTEiJ_G0018032	protein coding gene	Chr11:76582137-76585839 (+)
CBA/J	MGP_CBAJ_G0018448	protein coding gene	Chr11:82677122-82680779 (+)
DBA/2J	MGP_DBA2J_G0018557	protein coding gene	Chr11:73526208-73529865 (+)
FVB/NJ	MGP_FVBNJ_G0018547	protein coding gene	Chr11:73089380-73093037 (+)
LP/J	MGP_LPJ_G0018628	protein coding gene	Chr11:77369109-77372766 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018573	protein coding gene	Chr11:83188372-83192037 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019156	protein coding gene	Chr11:76376962-76380619 (+)
PWK/PhJ	MGP_PWKPhJ_G0017803	protein coding gene	Chr11:74245753-74249419 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017594	protein coding gene	Chr11:75944337-75948020 (+)
WSB/EiJ	MGP_WSBEiJ_G0018085	protein coding gene	Chr11:76194326-76197977 (+)

Human Ortholog

LIAT1, ligand of ATE1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LIAT1, ligand of ATE1
Synonyms

C17orf97, CK20
Links

HGNC:33800

NCBI Gene ID: 400566

neXtProt AC: NX_Q6ZQX7

UniProt: Q6ZQX7
Chr Location

17p13.3; chr17:410325-431062 (+) GRCh38

MGI Vertebrate Homology

Liat1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LIAT1
Gene Tree

Liat1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Gene trapped

3
Targeted

5
Genomic Mutations

2 involving Liat1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

7
cDNA Data

16
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

4
UniProt

1
CCDS

CCDS25059.1

Ensembl

ENSMUSG00000053783 (Evidence)
NCBI Gene

74230

			Length	Strain/Species	Flank
genomic	74230	NCBI Gene Model \| MGI Sequence Detail	3658	C57BL/6J	± kb
transcript	NM_198637	RefSeq \| MGI Sequence Detail	941	Not Specified
polypeptide	Q810M6	UniProt \| EBI \| MGI Sequence Detail	228	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR038794 Protein LIAT1

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All nucleic 16

cDNA 16

Microarray probesets 4

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MGI:7442467

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Liat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103068	Chr11:75890754-75890772 (+)	25 bp
Tssr103069	Chr11:75890778-75890803 (+)	53 bp
Tssr103070	Chr11:75890806-75890820 (+)	75 bp
Tssr103071	Chr11:75890832-75890837 (+)	97 bp
Tssr103072	Chr11:75890842-75890849 (+)	108 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24