Tubgcp2 MGI Mouse Gene Detail - MGI:1921487 - tubulin, gamma complex component 2

Symbol

Tubgcp2
Name

tubulin, gamma complex component 2
Synonyms

1700022B05Rik

Feature Type

protein coding gene
IDs

MGI:1921487
NCBI Gene: 74237
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:139575868-139616582 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 84.98 cM, cytoband F5
Mapping Data

2 experiments

SNPs within 2kb

908 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921487	protein coding gene	Chr7:139575868-139616587 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033158	protein coding gene	Chr7:145074339-145112832 (-)
A/J	MGP_AJ_G0033140	protein coding gene	Chr7:140960094-140986169 (-)
AKR/J	MGP_AKRJ_G0033072	protein coding gene	Chr7:144794406-144821844 (-)
BALB/cJ	MGP_BALBcJ_G0033141	protein coding gene	Chr7:140692903-140717177 (-)
C3H/HeJ	MGP_C3HHeJ_G0032855	protein coding gene	Chr7:144588166-144629982 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033652	protein coding gene	Chr7:150416522-150453672 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030625	protein coding gene	Chr7:142079312-142103251 (-)
CAST/EiJ	MGP_CASTEiJ_G0032185	protein coding gene	Chr7:136891268-136919237 (-)
CBA/J	MGP_CBAJ_G0032828	protein coding gene	Chr7:155485242-155514267 (-)
DBA/2J	MGP_DBA2J_G0032980	protein coding gene	Chr7:138906502-138946754 (-)
FVB/NJ	MGP_FVBNJ_G0032933	protein coding gene	Chr7:138796203-138836286 (-)
LP/J	MGP_LPJ_G0033074	protein coding gene	Chr7:146629206-146656490 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032965	protein coding gene	Chr7:156149095-156183152 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033672	protein coding gene	Chr7:143787790-143827985 (-)
PWK/PhJ	MGP_PWKPhJ_G0031891	protein coding gene	Chr7:132102104-132128880 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031736	protein coding gene	Chr7:130625805-130662894 (-)
WSB/EiJ	MGP_WSBEiJ_G0032296	protein coding gene	Chr7:144688952-144715681 (-)

Human Ortholog

TUBGCP2, tubulin gamma complex component 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TUBGCP2, tubulin gamma complex component 2
Synonyms

ALP4, GCP-2, GCP2, Grip103, h103p, hGCP2, hSpc97, PAMDDFS, SPBC97, SPC97, Spc97p
Links

HGNC:18599

NCBI Gene ID: 10844

neXtProt AC: NX_Q9BSJ2

UniProt: Q9BSJ2
Chr Location

10q26.3; chr10:133278635-133318823 (-) GRCh38

MGI Vertebrate Homology

Tubgcp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TUBGCP2
Gene Tree

Tubgcp2

Diseases

1 with human TUBGCP2 associations

				Human Disease	Mouse Models
				pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures IDs pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures DOID:0081266 OMIM:618737

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

7
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Tubgcp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, embryos hatch from the zona pellucida but form outgrowths with small/no ICM colony after 3 days in culture.

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All GO Annotations

23
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

7
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tubgcp2

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All Sequences

80
RefSeq

18
UniProt

8
CCDS

CCDS21960.1

Ensembl

ENSMUSG00000025474 (Evidence)
NCBI Gene

74237

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025474	Ensembl Gene Model \| MGI Sequence Detail	40715	C57BL/6J	± kb
transcript	ENSMUST00000026547	Ensembl \| MGI Sequence Detail	2960	Not Applicable
polypeptide	ENSMUSP00000026547	Ensembl \| MGI Sequence Detail	905	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000016827 gamma-tubulin complex component 2

(term hierarchy)
InterPro Domains

IPR040457 Gamma tubulin complex component, C-terminal

IPR042241 Gamma-tubulin complex component, C-terminal domain superfamily

IPR007259 Gamma-tubulin complex component protein

IPR041470 Gamma tubulin complex component protein, N-terminal

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All nucleic 13

cDNA 13

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 13
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tubgcp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75492	Chr7:139616539-139616588 (-)	18 bp
Tssr75491	Chr7:139616276-139616313 (-)	287 bp
Tssr75490	Chr7:139616246-139616263 (-)	327 bp
Tssr75489	Chr7:139616169-139616231 (-)	382 bp
Tssr75488	Chr7:139579002-139579016 (-)	37,573 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24