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Mterf2 Gene Detail
Summary
  • Symbol
    Mterf2
  • Name
    mitochondrial transcription termination factor 2
  • Synonyms
    1700007D05Rik, Mterfd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921488
    NCBI Gene: 74238
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:84955297-84963891 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 41.63 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    303 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921488
 protein coding gene Chr10:84951092-84963982 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017598
 protein coding gene Chr10:86021083-86029675 (-)
A/J MGP_AJ_G0017578
 protein coding gene Chr10:83094008-83102600 (-)
AKR/J MGP_AKRJ_G0017537
 protein coding gene Chr10:85408602-85417192 (-)
BALB/cJ MGP_BALBcJ_G0017541
 protein coding gene Chr10:83344073-83352666 (-)
C3H/HeJ MGP_C3HHeJ_G0017363
 protein coding gene Chr10:85495279-85503871 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017998
 protein coding gene Chr10:88939029-88947621 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015682
 protein coding gene Chr10:78966468-78974999 (-)
CAST/EiJ MGP_CASTEiJ_G0016930
 protein coding gene Chr10:85352782-85361437 (-)
CBA/J MGP_CBAJ_G0017333
 protein coding gene Chr10:92625801-92634393 (-)
DBA/2J MGP_DBA2J_G0017439
 protein coding gene Chr10:82237150-82245742 (-)
FVB/NJ MGP_FVBNJ_G0017433
 protein coding gene Chr10:81470417-81479009 (-)
LP/J MGP_LPJ_G0017511
 protein coding gene Chr10:86653498-86662088 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017461
 protein coding gene Chr10:94252788-94261382 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018035
 protein coding gene Chr10:85330973-85339565 (-)
PWK/PhJ MGP_PWKPhJ_G0016711
 protein coding gene Chr10:82107355-82115993 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016500
 protein coding gene Chr10:83959858-83968458 (-)
WSB/EiJ MGP_WSBEiJ_G0016989
 protein coding gene Chr10:85317406-85326153 (-)



Homology
more
  • Human Ortholog
    MTERF2, mitochondrial transcription termination factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTERF2, mitochondrial transcription termination factor 2
  • Synonyms
    MTERFD3, mTERFL
  • Links
    NCBI Gene ID: 80298
    neXtProt AC: NX_Q49AM1
    UniProt: Q49AM1

  • Chr Location
    12q23.3; chr12:106973120-106987163 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele gain less weight than wild-type controls, develop a myopathy, and show memory deficits, decreased levels of mitochondrial transcripts, an imbalanced tRNA pool, impaired oxidative phosphorylation, reduced respiratory function, and enlarged mitochondrial mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049038 Ensembl Gene Model | MGI Sequence Detail 8595 C57BL/6J ±  kb
    transcript ENSMUST00000050813 Ensembl | MGI Sequence Detail 1567 Not Applicable  
    polypeptide ENSMUSP00000062762 Ensembl | MGI Sequence Detail 385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010716 transcription termination factor 2, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR038538 MTERF superfamily, mitochondrial/chloroplastic
      IPR003690 Transcription termination factor, mitochondrial/chloroplastic
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory