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Gale Gene Detail
Summary
  • Symbol
    Gale
  • Name
    galactose-4-epimerase, UDP
  • Synonyms
    2310002A12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921496
    NCBI Gene: 74246
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135691038-135695489 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921496
 protein coding gene Chr4:135690550-135695489 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028955
 protein coding gene Chr4:138458719-138463159 (+)
A/J MGP_AJ_G0028914
 protein coding gene Chr4:132581405-132585857 (+)
AKR/J MGP_AKRJ_G0028866
 protein coding gene Chr4:136411431-136415902 (+)
BALB/cJ MGP_BALBcJ_G0028938
 protein coding gene Chr4:133251839-133256500 (+)
C3H/HeJ MGP_C3HHeJ_G0028652
 protein coding gene Chr4:136691658-136696094 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029379
 protein coding gene Chr4:143367303-143371779 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026650
 protein coding gene Chr4:125634167-125638618 (+)
CAST/EiJ MGP_CASTEiJ_G0028084
 protein coding gene Chr4:134828732-134834941 (+)
CBA/J MGP_CBAJ_G0028617
 protein coding gene Chr4:147309664-147316934 (+)
DBA/2J MGP_DBA2J_G0028766
 protein coding gene Chr4:133014012-133018455 (+)
FVB/NJ MGP_FVBNJ_G0028733
 protein coding gene Chr4:131933114-131937687 (+)
LP/J MGP_LPJ_G0028865
 protein coding gene Chr4:138557093-138561533 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028759
 protein coding gene Chr4:151583385-151589940 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029417
 protein coding gene Chr4:136863794-136868234 (+)
PWK/PhJ MGP_PWKPhJ_G0027804
 protein coding gene Chr4:129780749-129785269 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027630
 protein coding gene Chr4:132681092-132685533 (+)
WSB/EiJ MGP_WSBEiJ_G0028162
 protein coding gene Chr4:137040342-137044785 (+)



Homology
more
  • Human Ortholog
    GALE, UDP-galactose-4-epimerase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALE, UDP-galactose-4-epimerase
  • Synonyms
    SDR1E1, THC13
  • Links
    NCBI Gene ID: 2582
    neXtProt AC: NX_Q14376
    UniProt: Q14376

  • Chr Location
    1p36.11; chr1:23795599-23800781 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GALE associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    3
  • Targeted
    4
  • Genomic Mutations
    3 involving Gale
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    15 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1041
  • Tissues
    122
  • cDNA Data
    73
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028671 Ensembl Gene Model | MGI Sequence Detail 4452 C57BL/6J ±  kb
transcript ENSMUST00000102540 Ensembl | MGI Sequence Detail 1537 Not Applicable  
polypeptide ENSMUSP00000099599 Ensembl | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 74
    cDNA 73
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140236
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:245187 Zhu Y, et al., Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression. Diabetes. 2017 Nov;66(11):2789-2799
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory