Lrrc2 MGI Mouse Gene Detail - MGI:1921499 - leucine rich repeat containing 2

Symbol

Lrrc2
Name

leucine rich repeat containing 2
Synonyms

2400002D05Rik, 4933431K03Rik

Feature Type

protein coding gene
IDs

MGI:1921499
NCBI Gene: 74249
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr9:110780613-110813134 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 60.79 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

1178 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921499	protein coding gene	Chr9:110780613-110813134 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035366	protein coding gene	Chr9:113150971-113177042 (+)
A/J	MGP_AJ_G0035347	protein coding gene	Chr9:109019807-109048217 (+)
AKR/J	MGP_AKRJ_G0035278	protein coding gene	Chr9:111731078-111754701 (+)
BALB/cJ	MGP_BALBcJ_G0035342	protein coding gene	Chr9:108779217-108801223 (+)
C3H/HeJ	MGP_C3HHeJ_G0035050	protein coding gene	Chr9:112238265-112267370 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035864	protein coding gene	Chr9:116268061-116299177 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032750	protein coding gene	Chr9:106234714-106262380 (+)
CAST/EiJ	MGP_CASTEiJ_G0034356	protein coding gene	Chr9:112039946-112065873 (+)
CBA/J	MGP_CBAJ_G0035017	protein coding gene	Chr9:120551201-120577815 (+)
DBA/2J	MGP_DBA2J_G0035176	protein coding gene	Chr9:108479982-108503154 (+)
FVB/NJ	MGP_FVBNJ_G0035123	protein coding gene	Chr9:107321380-107346033 (+)
LP/J	MGP_LPJ_G0035255	protein coding gene	Chr9:113440198-113465630 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035163	protein coding gene	Chr9:121865771-121891843 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035884	protein coding gene	Chr9:112082266-112111106 (+)
PWK/PhJ	MGP_PWKPhJ_G0034063	protein coding gene	Chr9:108724671-108751682 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033898	protein coding gene	Chr9:112161355-112195686 (+)
WSB/EiJ	MGP_WSBEiJ_G0034477	protein coding gene	Chr9:111952807-111977357 (+)

Human Ortholog

LRRC2, leucine rich repeat containing 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC2, leucine rich repeat containing 2
Links

HGNC:14676

NCBI Gene ID: 79442

neXtProt AC: NX_Q9BYS8

UniProt: Q9BYS8
Chr Location

3p21.31; chr3:46515385-46606948 (-) GRCh38

MGI Vertebrate Homology

Lrrc2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LRRC2
Gene Tree

Lrrc2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

164
Endonuclease-mediated

1
Gene trapped

160
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

135 strains or lines available

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

2
cDNA Data

18
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrc2

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All Sequences

41
RefSeq

6
UniProt

4
CCDS

CCDS23580.1

Ensembl

ENSMUSG00000032495 (Evidence)
NCBI Gene

74249

			Length	Strain/Species	Flank
genomic	74249	NCBI Gene Model \| MGI Sequence Detail	32522	C57BL/6J	± kb
transcript	NM_028838	RefSeq \| MGI Sequence Detail	3657	ZRU/MplStud
polypeptide	Q8VDB8	UniProt \| EBI \| MGI Sequence Detail	371	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000030545 leucine-rich repeat-containing protein 2

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR025875 Leucine rich repeat 4

IPR050216 Leucine-rich repeat domain-containing protein

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

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All nucleic 20

cDNA 18

Primer pair 2

Microarray probesets 5

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MGI:1922983

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lrrc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87439	Chr9:110780795-110780813 (+)	191 bp
Tssr87440	Chr9:110782221-110782244 (+)	1,620 bp
Tssr87441	Chr9:110782505-110782507 (+)	1,893 bp
Tssr87442	Chr9:110782761-110782770 (+)	2,153 bp
Tssr87443	Chr9:110782794-110782824 (+)	2,196 bp
Tssr87444	Chr9:110782826-110782855 (+)	2,228 bp
Tssr87445	Chr9:110782857-110782875 (+)	2,253 bp
Tssr87446	Chr9:110782876-110782931 (+)	2,291 bp
Tssr87447	Chr9:110789520-110789545 (+)	8,920 bp
Tssr87448	Chr9:110789894-110789906 (+)	9,287 bp
Tssr87449	Chr9:110789911-110789942 (+)	9,314 bp
Tssr87450	Chr9:110789957-110789964 (+)	9,348 bp
Tssr87451	Chr9:110789995-110790009 (+)	9,389 bp
Tssr87452	Chr9:110794324-110794346 (+)	13,722 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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