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Usp20 Gene Detail
Summary
  • Symbol
    Usp20
  • Name
    ubiquitin specific peptidase 20
  • Synonyms
    1700055M05Rik, Vdu2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921520
    NCBI Gene: 74270
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30872291-30912667 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.77 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921520
 protein coding gene Chr2:30872291-30913598 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025580
 protein coding gene Chr2:29281295-29324109 (+)
A/J MGP_AJ_G0025558
 protein coding gene Chr2:28090098-28132961 (+)
AKR/J MGP_AKRJ_G0025527
 protein coding gene Chr2:29048844-29089919 (+)
BALB/cJ MGP_BALBcJ_G0025554
 protein coding gene Chr2:28225894-28267849 (+)
C3H/HeJ MGP_C3HHeJ_G0025315
 protein coding gene Chr2:28980383-29022794 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025999
 protein coding gene Chr2:30226127-30271952 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023407
 protein coding gene Chr2:26853865-26897170 (+)
CAST/EiJ MGP_CASTEiJ_G0024777
 protein coding gene Chr2:28913922-28957285 (+)
CBA/J MGP_CBAJ_G0025292
 protein coding gene Chr2:31304105-31346112 (+)
DBA/2J MGP_DBA2J_G0025425
 protein coding gene Chr2:27867578-27908702 (+)
FVB/NJ MGP_FVBNJ_G0025388
 protein coding gene Chr2:27709964-27751028 (+)
LP/J MGP_LPJ_G0025511
 protein coding gene Chr2:29188104-29232421 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025418
 protein coding gene Chr2:31086985-31132175 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026057
 protein coding gene Chr2:28961366-29006100 (+)
PWK/PhJ MGP_PWKPhJ_G0024524
 protein coding gene Chr2:27741837-27783846 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024324
 protein coding gene Chr2:29103304-29149233 (+)
WSB/EiJ MGP_WSBEiJ_G0024845
 protein coding gene Chr2:29137135-29181876 (+)



Homology
more
  • Human Ortholog
    USP20, ubiquitin specific peptidase 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP20, ubiquitin specific peptidase 20
  • Synonyms
    hVDU2, LSFR3A, VDU2
  • Links
    NCBI Gene ID: 10868
    neXtProt AC: NX_Q9Y2K6
    UniProt: Q9Y2K6

  • Chr Location
    9q34.11; chr9:129834698-129881828 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased diet-induced body weight gain, reduced lipid levels in the serum and liver, improved insulin sensitivity and increased energy expenditure. Another null allele shows increased susceptibility to lethal HSV-1 infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    10
  • cDNA Data
    68
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74270 NCBI Gene Model | MGI Sequence Detail 40377 C57BL/6J ±  kb
    transcript NM_028846 RefSeq | MGI Sequence Detail 4157 C57BL/6  
    polypeptide Q8C6M1 UniProt | EBI | MGI Sequence Detail 916 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 69
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138976
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory