About   Help   FAQ
Chic2 Gene Detail
Summary
  • Symbol
    Chic2
  • Name
    cysteine-rich hydrophobic domain 2
  • Synonyms
    1700081B18Rik, 4930502K01Rik, BTL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921527
    NCBI Gene: 74277
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:75165665-75205302 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 39.54 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    714 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921527
 protein coding gene Chr5:75158649-75205435 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029635
 protein coding gene Chr5:75107890-75155501 (-)
A/J MGP_AJ_G0029603
 protein coding gene Chr5:72253236-72300584 (-)
AKR/J MGP_AKRJ_G0029551
 protein coding gene Chr5:74607990-74654974 (-)
BALB/cJ MGP_BALBcJ_G0029612
 protein coding gene Chr5:72963229-73009876 (-)
C3H/HeJ MGP_C3HHeJ_G0029335
 protein coding gene Chr5:74989635-75040653 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030066
 protein coding gene Chr5:78135861-78183691 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027306
 protein coding gene Chr5:67927049-67975407 (-)
CAST/EiJ MGP_CASTEiJ_G0028743
 protein coding gene Chr5:74104814-74155492 (-)
CBA/J MGP_CBAJ_G0029304
 protein coding gene Chr5:80717641-80771622 (-)
DBA/2J MGP_DBA2J_G0029449
 protein coding gene Chr5:72332788-72381427 (-)
FVB/NJ MGP_FVBNJ_G0029410
 protein coding gene Chr5:71484581-71533515 (-)
LP/J MGP_LPJ_G0029535
 protein coding gene Chr5:75532373-75582570 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029437
 protein coding gene Chr5:83934075-83985494 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030099
 protein coding gene Chr5:74142575-74189656 (-)
PWK/PhJ MGP_PWKPhJ_G0028466
 protein coding gene Chr5:71327905-71372620 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028301
 protein coding gene Chr5:73498523-73550033 (-)
WSB/EiJ MGP_WSBEiJ_G0028823
 protein coding gene Chr5:74432359-74482142 (-)



Homology
more
  • Human Ortholog
    CHIC2, cysteine rich hydrophobic domain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHIC2, cysteine rich hydrophobic domain 2
  • Synonyms
    BTL
  • Links
    NCBI Gene ID: 26511
    neXtProt AC: NX_Q9UKJ5
    UniProt: Q9UKJ5

  • Chr Location
    4q12; chr4:54009789-54091879 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CHIC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    369 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    41
  • cDNA Data
    78
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74277 NCBI Gene Model | MGI Sequence Detail 39638 C57BL/6J ±  kb
    transcript NM_028850 RefSeq | MGI Sequence Detail 2550 C57BL/6  
    polypeptide Q9D9G3 UniProt | EBI | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031951 cysteine-rich hydrophobic domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR039735 Cysteine-rich hydrophobic domain-containing protein 1/2
      IPR019383 Golgin subfamily A member 7/ERF4
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 78

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922202
    References
    more
    • Summaries
      All 393
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 3
      Phenotypes 369
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory