Osbp2 MGI Mouse Gene Detail - MGI:1921559 - oxysterol binding protein 2

Symbol

Osbp2
Name

oxysterol binding protein 2
Synonyms

1700095P05Rik, C630001G20Rik, ORP-4, OSBPL1

Feature Type

protein coding gene
IDs

MGI:1921559
NCBI Gene: 74309
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:3653731-3813903 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.60 cM
Mapping Data

3 experiments

SNPs within 2kb

3830 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921559	protein coding gene	Chr11:3653731-3814000 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017963	protein coding gene	Chr11:594276-759334 (-)
A/J	MGP_AJ_G0017936	protein coding gene	Chr11:631392-794451 (-)
AKR/J	MGP_AKRJ_G0017900	protein coding gene	Chr11:649701-820266 (-)
BALB/cJ	MGP_BALBcJ_G0017904	protein coding gene	Chr11:595948-761305 (-)
C3H/HeJ	MGP_C3HHeJ_G0017717	protein coding gene	Chr11:581796-747425 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018357	protein coding gene	Chr11:667979-839183 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016016	protein coding gene	Chr11:533912-694121 (-)
CAST/EiJ	MGP_CASTEiJ_G0017279	protein coding gene	Chr11:549586-721035 (-)
CBA/J	MGP_CBAJ_G0017692	protein coding gene	Chr11:839990-1032002 (-)
DBA/2J	MGP_DBA2J_G0017803	protein coding gene	Chr11:542048-702958 (-)
FVB/NJ	MGP_FVBNJ_G0017794	protein coding gene	Chr11:573850-739679 (-)
LP/J	MGP_LPJ_G0017873	protein coding gene	Chr11:682464-851362 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017820	protein coding gene	Chr11:589443-754236 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018396	protein coding gene	Chr11:666573-837938 (-)
PWK/PhJ	MGP_PWKPhJ_G0017060	protein coding gene	Chr11:531408-695369 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016856	protein coding gene	Chr11:623132-793154 (-)
WSB/EiJ	MGP_WSBEiJ_G0017333	protein coding gene	Chr11:540670-711006 (-)

Human Ortholog

OSBP2, oxysterol binding protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OSBP2, oxysterol binding protein 2
Synonyms

HLM, ORP-4, ORP4, OSBPL1, OSBPL4
Links

HGNC:8504

NCBI Gene ID: 23762

neXtProt AC: NX_Q969R2

UniProt: Q969R2
Chr Location

22q12.2; chr22:30693782-30907824 (+) GRCh38

MGI Vertebrate Homology

Osbp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: OSBP2
Gene Tree

Osbp2

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility with sperm defects including oligozoospermia, teratozoospermia, asthenozoospermia and abnormal spermiogenesis.

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All GO Annotations

12
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

13
cDNA Data

45
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA OSBP2

Xenbase osbp2

ZFIN osbp2b

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All Sequences

118
RefSeq

68
UniProt

7
CCDS

CCDS24367.1, CCDS78912.1

Ensembl

ENSMUSG00000020435 (Evidence)
NCBI Gene

74309

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020435	Ensembl Gene Model \| MGI Sequence Detail	160173	C57BL/6J	± kb
transcript	ENSMUST00000070552	Ensembl \| MGI Sequence Detail	4097	Not Applicable
polypeptide	ENSMUSP00000068652	Ensembl \| MGI Sequence Detail	908	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012044 oxysterol-binding protein 2

(term hierarchy)
InterPro Domains

IPR000648 Oxysterol-binding protein

IPR018494 Oxysterol-binding protein, conserved site

IPR037239 Oxysterol-binding protein superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain
GlyGen

Q5QNQ6 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 46

cDNA 45

Primer pair 1

Microarray probesets 3

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MGI:2685090

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 3
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:351297 Ge T, et al., Coiled-coil domain containing 159 is required for spermatid head and tail assembly in mice. Biol Reprod. 2024 May 9;110(5):877-894

TSS for Osbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106510	Chr11:3813895-3813910 (-)	0 bp
Tssr106509	Chr11:3813869-3813886 (-)	25 bp
Tssr106508	Chr11:3813716-3813727 (-)	181 bp
Tssr106507	Chr11:3755210-3755252 (-)	58,672 bp
Tssr106506	Chr11:3725133-3725162 (-)	88,755 bp
Tssr106505	Chr11:3724706-3724738 (-)	89,181 bp
Tssr106504	Chr11:3724694-3724702 (-)	89,205 bp
Tssr106503	Chr11:3672189-3672222 (-)	141,697 bp
Tssr106502	Chr11:3672160-3672184 (-)	141,731 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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