Mettl23 MGI Mouse Gene Detail - MGI:1921569

Symbol

Mettl23
Name

methyltransferase like 23
Synonyms

1110005A03Rik, 1500035B17Rik, 4933424L15Rik

Feature Type

protein coding gene
IDs

MGI:1921569
NCBI Gene: 74319
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:116734341-116740566 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 81.49 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

194 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921569	protein coding gene	Chr11:116734104-116745089 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019441	protein coding gene	Chr11:121006125-121017114 (+)
A/J	MGP_AJ_G0019409	protein coding gene	Chr11:115668761-115673619 (+)
AKR/J	MGP_AKRJ_G0019379	protein coding gene	Chr11:119204311-119209123 (+)
BALB/cJ	MGP_BALBcJ_G0019384	protein coding gene	Chr11:116062138-116068354 (+)
C3H/HeJ	MGP_C3HHeJ_G0019190	protein coding gene	Chr11:119472600-119478801 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019833	protein coding gene	Chr11:124733729-124745419 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017456	protein coding gene	Chr11:112681214-112692203 (+)
CAST/EiJ	MGP_CASTEiJ_G0018744	protein coding gene	Chr11:120892263-120903263 (+)
CBA/J	MGP_CBAJ_G0019161	protein coding gene	Chr11:129593206-129599408 (+)
DBA/2J	MGP_DBA2J_G0019273	protein coding gene	Chr11:115091195-115096028 (+)
FVB/NJ	MGP_FVBNJ_G0019265	protein coding gene	Chr11:114650264-114661844 (+)
LP/J	MGP_LPJ_G0019343	protein coding gene	Chr11:121352774-121363727 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019298	protein coding gene	Chr11:128648124-128659771 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019872	protein coding gene	Chr11:119835415-119847288 (+)
PWK/PhJ	MGP_PWKPhJ_G0018509	protein coding gene	Chr11:116426335-116438353 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018302	protein coding gene	Chr11:119569073-119580109 (+)
WSB/EiJ	MGP_WSBEiJ_G0018796	protein coding gene	Chr11:119779624-119790607 (+)

Human Ortholog

METTL23, methyltransferase 23, arginine

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

METTL23, methyltransferase 23, arginine
Synonyms

C17orf95, MRT44
Links

HGNC:26988

NCBI Gene ID: 124512

neXtProt AC: NX_Q86XA0

UniProt: Q86XA0
Chr Location

17q25.1; chr17:76726041-76733936 (+) GRCh38

MGI Vertebrate Homology

Mettl23 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: METTL23
Gene Tree

Mettl23

Diseases

1 with Mettl23 mouse models; 1 with human METTL23 associations

Human Disease

Mouse Models

glaucoma

IDs

View 4 models

autosomal recessive intellectual developmental disorder 44

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

27 phenotypes from 4 alleles in 4 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

6
Gene trapped

7
Targeted

3
Genomic Mutations

2 involving Mettl23
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit normal-tension glaucoma with loss of retinal ganglion cells and optic nerve atrophy. Mice homozygous for a different null allele show partial postnatal lethality, low survivor rate, decreased litter size, and abnormal active DNA demethylation of the paternal genome.

less

All GO Annotations

26
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

1
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mettl23

less

All Sequences

55
RefSeq

6
UniProt

4
CCDS

CCDS25679.2

Ensembl

ENSMUSG00000090266 (Evidence)
NCBI Gene

74319

			Length	Strain/Species	Flank
genomic	74319	NCBI Gene Model \| MGI Sequence Detail	6226	C57BL/6J	± kb
transcript	NM_028865	RefSeq \| MGI Sequence Detail	1055	C57BL/6
polypeptide	A2AA28	UniProt \| EBI \| MGI Sequence Detail	253	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000030521 histone-arginine methyltransferase METTL23

(term hierarchy)
EC

2.1.1.319
InterPro Domains

IPR019410 Lysine methyltransferase

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

less

All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 7

less

MGI:1918365, MGI:1923742

Summaries

All 39

Developmental Gene Expression 2

Diseases 1

Gene Ontology 6

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mettl23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105996	Chr11:116734345-116734395 (+)	29 bp
Tssr105997	Chr11:116734398-116734429 (+)	73 bp
Tssr105998	Chr11:116734477-116734503 (+)	149 bp
Tssr105999	Chr11:116734533-116734556 (+)	204 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24