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Cxxc1 Gene Detail
Summary
  • Symbol
    Cxxc1
  • Name
    CXXC finger protein 1
  • Synonyms
    2410002I16Rik, 5830420C16Rik, Cfp1, Cgbp, CXXC finger 1 (PHD domain), PHF18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921572
    NCBI Gene: 74322
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:74349283-74354564 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 50.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921572
 protein coding gene Chr18:74349195-74354567 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024555
 protein coding gene Chr18:74837899-74843259 (+)
A/J MGP_AJ_G0024522
 protein coding gene Chr18:71578633-71583981 (+)
AKR/J MGP_AKRJ_G0024493
 protein coding gene Chr18:73700977-73706325 (+)
BALB/cJ MGP_BALBcJ_G0024522
 protein coding gene Chr18:71750464-71755812 (+)
C3H/HeJ MGP_C3HHeJ_G0024290
 protein coding gene Chr18:73784840-73790188 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024968
 protein coding gene Chr18:76799393-76804753 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022399
 protein coding gene Chr18:70674623-70679990 (+)
CAST/EiJ MGP_CASTEiJ_G0023763
 protein coding gene Chr18:73967220-73972567 (+)
CBA/J MGP_CBAJ_G0024259
 protein coding gene Chr18:79420006-79425354 (+)
DBA/2J MGP_DBA2J_G0024389
 protein coding gene Chr18:71170328-71175676 (+)
FVB/NJ MGP_FVBNJ_G0024355
 protein coding gene Chr18:70515436-70520784 (+)
LP/J MGP_LPJ_G0024473
 protein coding gene Chr18:74710296-74715656 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024385
 protein coding gene Chr18:80875921-80881269 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025016
 protein coding gene Chr18:73828308-73833656 (+)
PWK/PhJ MGP_PWKPhJ_G0023507
 protein coding gene Chr18:71535473-71540826 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023312
 protein coding gene Chr18:73988946-73994285 (+)
WSB/EiJ MGP_WSBEiJ_G0023826
 protein coding gene Chr18:73780075-73785423 (+)



Homology
more
  • Human Ortholog
    CXXC1, CXXC finger protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXXC1, CXXC finger protein 1
  • Synonyms
    2410002I16Rik, 5830420C16Rik, CFP1, CGBP, hCGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1
  • Links
    NCBI Gene ID: 30827
    neXtProt AC: NX_Q9P0U4
    UniProt: Q9P0U4

  • Chr Location
    18q21.1; chr18:50282343-50287839 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit peri-implantation lethality and failure to gastrulate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    90
  • cDNA Data
    99
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74322 NCBI Gene Model | MGI Sequence Detail 5282 C57BL/6J ±  kb
    transcript NM_001378844 RefSeq | MGI Sequence Detail 2551 C57BL/6  
    polypeptide Q9CWW7 UniProt | EBI | MGI Sequence Detail 660 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      cDNA 100
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923314, MGI:2147221
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 24
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347631 Li C, et al., Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Adv Sci (Weinh). 2024 Mar;11(11):e2305992
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory