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Cltb Gene Detail
Summary
  • Symbol
    Cltb
  • Name
    clathrin light chain B
  • Synonyms
    2310046E19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921575
    NCBI Gene: 74325
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:54740214-54759157 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 28.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    528 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921575
 protein coding gene Chr13:54740199-54759186 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020574
 protein coding gene Chr13:53998685-54017607 (-)
A/J MGP_AJ_G0020528
 protein coding gene Chr13:52017407-52036350 (-)
AKR/J MGP_AKRJ_G0020506
 protein coding gene Chr13:53546108-53566057 (-)
BALB/cJ MGP_BALBcJ_G0020524
 protein coding gene Chr13:52249376-52269929 (-)
C3H/HeJ MGP_C3HHeJ_G0020323
 protein coding gene Chr13:53371497-53390320 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020958
 protein coding gene Chr13:55653320-55673983 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018540
 protein coding gene Chr13:50012405-50032585 (-)
CAST/EiJ MGP_CASTEiJ_G0019837
 protein coding gene Chr13:53450787-53473001 (-)
CBA/J MGP_CBAJ_G0020283
 protein coding gene Chr13:57766335-57788748 (-)
DBA/2J MGP_DBA2J_G0020406
 protein coding gene Chr13:51585987-51605116 (-)
FVB/NJ MGP_FVBNJ_G0020385
 protein coding gene Chr13:51033822-51052932 (-)
LP/J MGP_LPJ_G0020482
 protein coding gene Chr13:54273601-54293736 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020414
 protein coding gene Chr13:57262125-57286821 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021001
 protein coding gene Chr13:53141309-53161212 (-)
PWK/PhJ MGP_PWKPhJ_G0019593
 protein coding gene Chr13:51572631-51591950 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019420
 protein coding gene Chr13:52056439-52075959 (-)
WSB/EiJ MGP_WSBEiJ_G0019899
 protein coding gene Chr13:53479111-53499122 (-)



Homology
more
  • Human Ortholog
    CLTB, clathrin light chain B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLTB, clathrin light chain B
  • Synonyms
    LCB
  • Links
    NCBI Gene ID: 1212
    neXtProt AC: NX_P09497
    UniProt: P09497

  • Chr Location
    5q35.2; chr5:176392455-176416569 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    57
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    47
  • Targeted
    7
  • Genomic Mutations
    2 involving Cltb
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    21 strains or lines available
Mice homozygous for a knock-out allele exhibit abnormal synaptic vesicle recycling and increased synaptic vesicle number with no apparent defects in neurotransmission, survival or motor coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    19
  • cDNA Data
    95
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047547 Ensembl Gene Model | MGI Sequence Detail 18944 C57BL/6J ±  kb
transcript ENSMUST00000049575 Ensembl | MGI Sequence Detail 1004 Not Applicable  
polypeptide ENSMUSP00000053371 Ensembl | MGI Sequence Detail 229 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 98
    Genomic 1
    cDNA 97

    Microarray probesets 5
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:342357 Chen Y, et al., Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formation. Life Sci Alliance. 2024 Jan;7(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory