Meak7 MGI Mouse Gene Detail - MGI:1921597 - MTOR associated protein, eak-7 homolog

Symbol

Meak7
Name

MTOR associated protein, eak-7 homolog
Synonyms

4632415K11Rik, Tldc1

Feature Type

protein coding gene
IDs

MGI:1921597
NCBI Gene: 74347
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:120486815-120505155 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 68.32 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

778 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921597	protein coding gene	Chr8:120486802-120505173 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034192	protein coding gene	Chr8:123117328-123135081 (-)
A/J	MGP_AJ_G0034172	protein coding gene	Chr8:118035890-118053747 (-)
AKR/J	MGP_AKRJ_G0034099	protein coding gene	Chr8:121466836-121484697 (-)
BALB/cJ	MGP_BALBcJ_G0034166	protein coding gene	Chr8:118241944-118260187 (-)
C3H/HeJ	MGP_C3HHeJ_G0033877	protein coding gene	Chr8:122191638-122212204 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034686	protein coding gene	Chr8:127224763-127246230 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031628	protein coding gene	Chr8:110930890-110949009 (-)
CAST/EiJ	MGP_CASTEiJ_G0033204	protein coding gene	Chr8:122141306-122158903 (-)
CBA/J	MGP_CBAJ_G0033850	protein coding gene	Chr8:131857036-131878638 (-)
DBA/2J	MGP_DBA2J_G0034006	protein coding gene	Chr8:117256990-117274635 (-)
FVB/NJ	MGP_FVBNJ_G0033949	protein coding gene	Chr8:116296667-116315535 (-)
LP/J	MGP_LPJ_G0034095	protein coding gene	Chr8:123249452-123267305 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033996	protein coding gene	Chr8:134309082-134326893 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034704	protein coding gene	Chr8:121618879-121639689 (-)
PWK/PhJ	MGP_PWKPhJ_G0032906	protein coding gene	Chr8:117013211-117031900 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032746	protein coding gene	Chr8:120318918-120336715 (-)
WSB/EiJ	MGP_WSBEiJ_G0033320	protein coding gene	Chr8:122341199-122359015 (-)

Human Ortholog

MEAK7, MTOR associated protein, eak-7 homolog

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEAK7, MTOR associated protein, eak-7 homolog
Synonyms

EAK7, KIAA1609, mEAK-7, TLDC1
Links

HGNC:29325

NCBI Gene ID: 57707

neXtProt AC: NX_Q6P9B6

UniProt: Q6P9B6
Chr Location

16q24.1; chr16:84476355-84554033 (-) GRCh38

MGI Vertebrate Homology

Meak7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MEAK7
Gene Tree

Meak7

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

30
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

13
cDNA Data

17
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase meak7

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All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS40494.1

Ensembl

ENSMUSG00000034105 (Evidence)
NCBI Gene

74347

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034105	Ensembl Gene Model \| MGI Sequence Detail	18341	C57BL/6J	± kb
transcript	ENSMUST00000049156	Ensembl \| MGI Sequence Detail	3085	Not Applicable
polypeptide	ENSMUSP00000044430	Ensembl \| MGI Sequence Detail	455	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000059866 MTOR-associated protein MEAK7

(term hierarchy)
InterPro Domains

IPR006571 TLDc domain

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All nucleic 20

cDNA 18

Primer pair 1

Other 1

Microarray probesets 2

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MGI:6276257

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Meak7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83156	Chr8:120505119-120505170 (-)	10 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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