Spag17 MGI Mouse Gene Detail - MGI:1921612 - sperm associated antigen 17

Symbol

Spag17
Name

sperm associated antigen 17
Synonyms

4931427F14Rik, PF6

Feature Type

protein coding gene
IDs

MGI:1921612
NCBI Gene: 74362
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:99792722-100050638 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 43.25 cM, cytoband F3
Mapping Data

2 experiments

SNPs within 2kb

4227 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921612	protein coding gene	Chr3:99792653-100050638 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027664	protein coding gene	Chr3:100998428-101263086 (+)
A/J	MGP_AJ_G0027623	protein coding gene	Chr3:97780134-98042412 (+)
AKR/J	MGP_AKRJ_G0027589	protein coding gene	Chr3:100140642-100419917 (+)
BALB/cJ	MGP_BALBcJ_G0027636	protein coding gene	Chr3:97562221-97822397 (+)
C3H/HeJ	MGP_C3HHeJ_G0027365	protein coding gene	Chr3:100466794-100737534 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028079	protein coding gene	Chr3:104688911-104980664 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025420	protein coding gene	Chr3:94022102-94270976 (+)
CAST/EiJ	MGP_CASTEiJ_G0026821	protein coding gene	Chr3:99588063-99852495 (+)
CBA/J	MGP_CBAJ_G0027340	protein coding gene	Chr3:108356205-108603435 (+)
DBA/2J	MGP_DBA2J_G0027483	protein coding gene	Chr3:97034239-97293876 (+)
FVB/NJ	MGP_FVBNJ_G0027451	protein coding gene	Chr3:94979929-95245618 (+)
LP/J	MGP_LPJ_G0027590	protein coding gene	Chr3:102345435-102602137 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027481	protein coding gene	Chr3:114526693-114812525 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028134	protein coding gene	Chr3:99668540-99923395 (+)
PWK/PhJ	MGP_PWKPhJ_G0026548	protein coding gene	Chr3:96793975-97049658 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026370	protein coding gene	Chr3:97770150-98045126 (+)
WSB/EiJ	MGP_WSBEiJ_G0026901	protein coding gene	Chr3:100241917-100502107 (+)

Human Ortholog

SPAG17, sperm associated antigen 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPAG17, sperm associated antigen 17
Synonyms

CT143, PF6, SPGF55
Links

HGNC:26620

NCBI Gene ID: 200162

neXtProt AC: NX_Q6Q759

UniProt: Q6Q759
Chr Location

1p12; chr1:117953590-118185228 (-) GRCh38

MGI Vertebrate Homology

Spag17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPAG17
Gene Tree

Spag17

Diseases

1 with human SPAG17 associations

				Human Disease	Mouse Models
				spermatogenic failure 55 IDs spermatogenic failure 55 DOID:0112337 OMIM:619380

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

less

Phenotype Summary

44 phenotypes from 3 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Spag17
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

108 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice show immotile respiratory cilia, impaired mucociliary clearance, respiratory distress, pulmonary edema, disrupted alveolar epithelia, hydrocephaly and neonatal death. Males show sterility, oligospermia, immotile sperm, abnormal sperm head and tails, and altered manchette structure.

less

All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

14
cDNA Data

6
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spag17

less

All Sequences

40
RefSeq

4
UniProt

1
CCDS

CCDS57248.1

Ensembl

ENSMUSG00000027867 (Evidence)
NCBI Gene

74362

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027867	Ensembl Gene Model \| MGI Sequence Detail	257917	C57BL/6J	± kb
transcript	ENSMUST00000164539	Ensembl \| MGI Sequence Detail	7862	Not Applicable
polypeptide	ENSMUSP00000134066	Ensembl \| MGI Sequence Detail	2320	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000015456 sperm-associated antigen 17

(term hierarchy)
InterPro Domains

IPR026173 Sperm-associated antigen 17
GlyGen

Q5S003 2 sites, 1 O-linked glycan (2 sites)

less

All nucleic 6

cDNA 6

Microarray probesets 4

Summaries

All 38

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Spag17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30866	Chr3:99792699-99792735 (+)	-5 bp
Tssr30867	Chr3:99792741-99792755 (+)	26 bp
Tssr30868	Chr3:99792764-99792804 (+)	62 bp
Tssr30869	Chr3:99876236-99876239 (+)	83,516 bp
Tssr30870	Chr3:99888581-99888619 (+)	95,878 bp
Tssr30871	Chr3:99888632-99888654 (+)	95,921 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24