About   Help   FAQ
Myo18b Gene Detail
Summary
  • Symbol
    Myo18b
  • Name
    myosin XVIIIb
  • Synonyms
    4932408L24Rik, 4933411E19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921626
    NCBI Gene: 74376
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:112836742-113044228 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 54.80 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6733 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921626
 protein coding gene Chr5:112836742-113044311 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029910
 protein coding gene Chr5:115294385-115513566 (-)
A/J MGP_AJ_G0029876
 protein coding gene Chr5:110803224-111015387 (-)
AKR/J MGP_AKRJ_G0029814
 protein coding gene Chr5:114315186-114530456 (-)
BALB/cJ MGP_BALBcJ_G0029887
 protein coding gene Chr5:112163828-112375372 (-)
C3H/HeJ MGP_C3HHeJ_G0029607
 protein coding gene Chr5:114755751-114967641 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030340
 protein coding gene Chr5:119783108-120009507 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027569
 protein coding gene Chr5:105625622-105834523 (-)
CAST/EiJ MGP_CASTEiJ_G0029015
 protein coding gene Chr5:113670813-113893010 (-)
CBA/J MGP_CBAJ_G0029574
 protein coding gene Chr5:124286593-124526848 (-)
DBA/2J MGP_DBA2J_G0029724
 protein coding gene Chr5:110864370-111077502 (-)
FVB/NJ MGP_FVBNJ_G0029681
 protein coding gene Chr5:109600459-109814072 (-)
LP/J MGP_LPJ_G0029812
 protein coding gene Chr5:115853440-116076643 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029712
 protein coding gene Chr5:128857601-129076527 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030381
 protein coding gene Chr5:113749660-113965213 (-)
PWK/PhJ MGP_PWKPhJ_G0028729
 protein coding gene Chr5:109484247-109696079 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028567
 protein coding gene Chr5:111242484-111463576 (-)
WSB/EiJ MGP_WSBEiJ_G0029091
 protein coding gene Chr5:114276260-114495230 (-)



Homology
more
  • Human Ortholog
    MYO18B, myosin XVIIIB
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYO18B, myosin XVIIIB
  • Synonyms
    KFS4
  • Links
    NCBI Gene ID: 84700
    neXtProt AC: NX_Q8IUG5
    UniProt: Q8IUG5

  • Chr Location
    22q12.1; chr22:25742144-26063847 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MYO18B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis with internal hemorrhage, pericaridal effusion, enlargement of the right atrium, and cardiac myofibril abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    18
  • cDNA Data
    6
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000072720 Ensembl Gene Model | MGI Sequence Detail 207487 C57BL/6J ±  kb
    transcript ENSMUST00000086617 Ensembl | MGI Sequence Detail 8280 Not Applicable  
    polypeptide ENSMUSP00000083810 Ensembl | MGI Sequence Detail 2605 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR036064 Class XVIII myosin, motor domain
      IPR000048 IQ motif, EF-hand binding site
      IPR036961 Kinesin motor domain superfamily
      IPR001609 Myosin head, motor domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      E9PV66 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 7
      Primer pair 1

      Microarray probesets 18
    Other
    Accession IDs
    less
    MGI:2685294
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory