Hsf2bp MGI Mouse Gene Detail - MGI:1921627 - heat shock transcription factor 2 binding protein

Symbol

Hsf2bp
Name

heat shock transcription factor 2 binding protein
Synonyms

4932437G14Rik

Feature Type

protein coding gene
IDs

MGI:1921627
NCBI Gene: 74377
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:32163743-32253869 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.25 cM
Mapping Data

2 experiments

SNPs within 2kb

2199 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921627	protein coding gene	Chr17:32163743-32255323 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023496	protein coding gene	Chr17:31755608-31849174 (-)
A/J	MGP_AJ_G0023453	protein coding gene	Chr17:30707981-30800696 (-)
AKR/J	MGP_AKRJ_G0023419	protein coding gene	Chr17:30981411-31068326 (-)
BALB/cJ	MGP_BALBcJ_G0023458	protein coding gene	Chr17:30782090-30890764 (-)
C3H/HeJ	MGP_C3HHeJ_G0023220	protein coding gene	Chr17:31354172-31444809 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023901	protein coding gene	Chr17:32858952-32946469 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021375	protein coding gene	Chr17:27825334-27906750 (-)
CAST/EiJ	MGP_CASTEiJ_G0022721	protein coding gene	Chr17:31431999-31508119 (-)
CBA/J	MGP_CBAJ_G0023195	protein coding gene	Chr17:34257536-34359425 (-)
DBA/2J	MGP_DBA2J_G0023325	protein coding gene	Chr17:30093488-30179414 (-)
FVB/NJ	MGP_FVBNJ_G0023295	protein coding gene	Chr17:29912610-30001659 (-)
LP/J	MGP_LPJ_G0023403	protein coding gene	Chr17:31965447-32058525 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023313	protein coding gene	Chr17:33344614-33433977 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023943	protein coding gene	Chr17:31345675-31430449 (-)
PWK/PhJ	MGP_PWKPhJ_G0022470	protein coding gene	Chr17:28970473-29060884 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022289	protein coding gene	Chr17:29329355-29426813 (-)
WSB/EiJ	MGP_WSBEiJ_G0022783	protein coding gene	Chr17:31317278-31404775 (-)

Human Ortholog

HSF2BP, heat shock transcription factor 2 binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSF2BP, heat shock transcription factor 2 binding protein
Synonyms

MEILB2, POF19
Links

HGNC:5226

NCBI Gene ID: 11077

neXtProt AC: NX_O75031

UniProt: O75031
Chr Location

21q22.3; chr21:43444972-43659488 (-) GRCh38

MGI Vertebrate Homology

Hsf2bp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSF2BP
Gene Tree

Hsf2bp

Diseases

1 with Hsf2bp mouse models; 1 with human HSF2BP associations

Human Disease

Mouse Models

primary ovarian insufficiency 19

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

3 with disease annotations

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Phenotype Summary

30 phenotypes from 5 alleles in 5 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

5
Gene trapped

9
Targeted

5
Genomic Mutations

2 involving Hsf2bp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects double-stranded DNA break repair, resulting in abnormal meiosis, which in turn leads to male sterility. KO mice are born at lower than expected Mendelian ratio.

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All GO Annotations

19
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

890
Tissues

147
cDNA Data

14
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hsf2bp

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All Sequences

48
RefSeq

6
UniProt

3
CCDS

CCDS50056.1

Ensembl

ENSMUSG00000002076 (Evidence)
NCBI Gene

74377

			Length	Strain/Species	Flank
genomic	74377	NCBI Gene Model \| MGI Sequence Detail	90127	C57BL/6J	± kb
transcript	NM_028902	RefSeq \| MGI Sequence Detail	2867	C57BL/6
polypeptide	Q9D4G2	UniProt \| EBI \| MGI Sequence Detail	338	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008792 heat shock factor 2-binding protein

(term hierarchy)
PDB

7Z8Z
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR039584 Heat shock factor 2-binding protein

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All nucleic 19

Genomic 1

cDNA 14

Primer pair 3

Other 1

Microarray probesets 6

Summaries

All 65

Developmental Gene Expression 8

Diseases 3

Gene Ontology 10

Phenotypes 35
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hsf2bp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147342	Chr17:32255288-32255304 (-)	-1,427 bp
Tssr147341	Chr17:32253504-32253513 (-)	360 bp
Tssr147340	Chr17:32253467-32253497 (-)	387 bp
Tssr147339	Chr17:32240914-32240922 (-)	12,951 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24