Terb2 MGI Mouse Gene Detail - MGI:1921651 - telomere repeat binding bouquet formation protein 2

Symbol

Terb2
Name

telomere repeat binding bouquet formation protein 2
Synonyms

4933406J08Rik

Feature Type

protein coding gene
IDs

MGI:1921651
NCBI Gene: 74401
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:122016753-122036874 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.56 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

697 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921651	protein coding gene	Chr2:122016753-122036878 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026408	protein coding gene	Chr2:125175296-125194688 (+)
A/J	MGP_AJ_G0026370	protein coding gene	Chr2:120058746-120077625 (+)
AKR/J	MGP_AKRJ_G0026347	protein coding gene	Chr2:123422702-123441544 (+)
BALB/cJ	MGP_BALBcJ_G0026382	protein coding gene	Chr2:120294041-120312686 (+)
C3H/HeJ	MGP_C3HHeJ_G0026127	protein coding gene	Chr2:123908205-123926818 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026829	protein coding gene	Chr2:129236993-129258737 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024208	protein coding gene	Chr2:115032809-115051012 (+)
CAST/EiJ	MGP_CASTEiJ_G0025589	protein coding gene	Chr2:124243970-124262466 (+)
CBA/J	MGP_CBAJ_G0026106	protein coding gene	Chr2:133793638-133812462 (+)
DBA/2J	MGP_DBA2J_G0026243	protein coding gene	Chr2:119458246-119477018 (+)
FVB/NJ	MGP_FVBNJ_G0026205	protein coding gene	Chr2:118247999-118266827 (+)
LP/J	MGP_LPJ_G0026345	protein coding gene	Chr2:125428504-125448106 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026225	protein coding gene	Chr2:138003270-138024905 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026884	protein coding gene	Chr2:123539247-123558102 (+)
PWK/PhJ	MGP_PWKPhJ_G0025325	protein coding gene	Chr2:119067847-119088153 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025125	protein coding gene	Chr2:122679040-122701642 (+)
WSB/EiJ	MGP_WSBEiJ_G0025661	protein coding gene	Chr2:124396205-124416633 (+)

Human Ortholog

TERB2, telomere repeat binding bouquet formation protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TERB2, telomere repeat binding bouquet formation protein 2
Synonyms

C15orf43, SPGF59
Links

HGNC:28520

NCBI Gene ID: 145645

neXtProt AC: NX_Q8NHR7

UniProt: Q8NHR7
Chr Location

15q21.1; chr15:44956687-44979229 (+) GRCh38

MGI Vertebrate Homology

Terb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TERB2
Gene Tree

Terb2

Diseases

1 with human TERB2 associations

				Human Disease	Mouse Models
				spermatogenic failure 59 IDs spermatogenic failure 59 DOID:0112357 OMIM:619645

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Terb2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit sterility due to arrested meiosis.

less

All GO Annotations

29
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase terb2

ZFIN terb2

less

All Sequences

29
RefSeq

2
UniProt

2
CCDS

CCDS50688.1

Ensembl

ENSMUSG00000027229 (Evidence)
NCBI Gene

74401

			Length	Strain/Species	Flank
genomic	74401	NCBI Gene Model \| MGI Sequence Detail	20122	C57BL/6J	± kb
transcript	NM_028914	RefSeq \| MGI Sequence Detail	2111	C57BL/6
polypeptide	Q9D494	UniProt \| EBI \| MGI Sequence Detail	218	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000059965 telomere repeats-binding bouquet formation protein 2

(term hierarchy)
InterPro Domains

IPR028065 Telomere repeats-binding bouquet formation protein 2

less

All nucleic 5

cDNA 5

Microarray probesets 2

Summaries

All 26

Gene Ontology 3

Phenotypes 9
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:346053 Zhang J, et al., Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nat Commun. 2024 Mar 14;15(1):2315

TSS for Terb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19833	Chr2:122016749-122016766 (+)	5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24