Eaf1 MGI Mouse Gene Detail - MGI:1921677

Symbol

Eaf1
Name

ELL associated factor 1
Synonyms

4933403C17Rik

Feature Type

protein coding gene
IDs

MGI:1921677
NCBI Gene: 74427
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:31217036-31231815 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 19.14 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

354 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921677	protein coding gene	Chr14:31216356-31231815 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021130	protein coding gene	Chr14:24683424-24698203 (+)
A/J	MGP_AJ_G0021078	protein coding gene	Chr14:23751545-23766326 (+)
AKR/J	MGP_AKRJ_G0021055	protein coding gene	Chr14:24874706-24889485 (+)
BALB/cJ	MGP_BALBcJ_G0021082	protein coding gene	Chr14:23883199-23897978 (+)
C3H/HeJ	MGP_C3HHeJ_G0020865	protein coding gene	Chr14:24746119-24760898 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021514	protein coding gene	Chr14:25658685-25673464 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019077	protein coding gene	Chr14:23822196-23837021 (+)
CAST/EiJ	MGP_CASTEiJ_G0020390	protein coding gene	Chr14:24528671-24543470 (+)
CBA/J	MGP_CBAJ_G0020832	protein coding gene	Chr14:26633558-26648337 (+)
DBA/2J	MGP_DBA2J_G0020954	protein coding gene	Chr14:23789340-23804119 (+)
FVB/NJ	MGP_FVBNJ_G0020938	protein coding gene	Chr14:23742438-23757221 (+)
LP/J	MGP_LPJ_G0021023	protein coding gene	Chr14:25009613-25024392 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020964	protein coding gene	Chr14:25886874-25901652 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021547	protein coding gene	Chr14:24642069-24656847 (+)
PWK/PhJ	MGP_PWKPhJ_G0020138	protein coding gene	Chr14:23245862-23260678 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019962	protein coding gene	Chr14:24245005-24262752 (+)
WSB/EiJ	MGP_WSBEiJ_G0020445	protein coding gene	Chr14:24705322-24720097 (+)

Human Ortholog

EAF1, ELL associated factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EAF1, ELL associated factor 1
Links

HGNC:20907

NCBI Gene ID: 85403

neXtProt AC: NX_Q96JC9

UniProt: Q96JC9
Chr Location

3p25.1; chr3:15427598-15450635 (+) GRCh38

MGI Vertebrate Homology

Eaf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EAF1
Gene Tree

Eaf1

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Gene trapped

10
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout is embryonic lethal. Conditional homozygous KO in prostate epithelium leads to prostate inflammation and an increased prostatic intraepithelial neoplasia incidence.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

769
Tissues

39
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eaf1

ZFIN eaf1

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All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS26914.1

Ensembl

ENSMUSG00000021890 (Evidence)
NCBI Gene

74427

			Length	Strain/Species	Flank
genomic	74427	NCBI Gene Model \| MGI Sequence Detail	14780	C57BL/6J	± kb
transcript	NM_028932	RefSeq \| MGI Sequence Detail	4238	C57BL/6
polypeptide	Q9D4C5	UniProt \| EBI \| MGI Sequence Detail	268	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006861 ELL-associated factor 1

(term hierarchy)
InterPro Domains

IPR027093 EAF family

IPR019194 Transcription elongation factor Eaf, N-terminal
GlyGen

Q9D4C5 1 site, 1 N-linked glycan (1 site)

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All nucleic 12

cDNA 12

Microarray probesets 7

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MGI:2145687

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eaf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124943	Chr14:31216305-31216324 (+)	-721 bp
Tssr124944	Chr14:31217022-31217052 (+)	1 bp
Tssr124945	Chr14:31217054-31217138 (+)	60 bp
Tssr124946	Chr14:31218374-31218380 (+)	1,341 bp
Tssr124947	Chr14:31222080-31222082 (+)	5,045 bp
Tssr124948	Chr14:31228471-31228473 (+)	11,436 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24