Tasor MGI Mouse Gene Detail - MGI:1921694 - transcription activation suppressor

Symbol

Tasor
Name

transcription activation suppressor
Synonyms

4933409E02Rik, D14Abb1e, Fam208a, MommeD6

Feature Type

protein coding gene
IDs

MGI:1921694
NCBI Gene: 218850
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:27150791-27205512 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 16.51 cM, cytoband B
Mapping Data

4 experiments

SNPs within 2kb

867 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921694	protein coding gene	Chr14:27150759-27205512 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021092	protein coding gene	Chr14:20444554-20498295 (+)
A/J	MGP_AJ_G0021040	protein coding gene	Chr14:19644715-19699412 (+)
AKR/J	MGP_AKRJ_G0021017	protein coding gene	Chr14:20705055-20757765 (+)
BALB/cJ	MGP_BALBcJ_G0021044	protein coding gene	Chr14:19757337-19811741 (+)
C3H/HeJ	MGP_C3HHeJ_G0020827	protein coding gene	Chr14:20565689-20619068 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021476	protein coding gene	Chr14:21294256-21362671 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019039	protein coding gene	Chr14:19767362-19822250 (+)
CAST/EiJ	MGP_CASTEiJ_G0020352	protein coding gene	Chr14:20199226-20263421 (+)
CBA/J	MGP_CBAJ_G0020794	protein coding gene	Chr14:22140612-22200154 (+)
DBA/2J	MGP_DBA2J_G0020916	protein coding gene	Chr14:19719385-19772102 (+)
FVB/NJ	MGP_FVBNJ_G0020900	protein coding gene	Chr14:19680156-19732728 (+)
LP/J	MGP_LPJ_G0020985	protein coding gene	Chr14:20750810-20812842 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020926	protein coding gene	Chr14:21475792-21538485 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021509	protein coding gene	Chr14:20459218-20515769 (+)
PWK/PhJ	MGP_PWKPhJ_G0020100	protein coding gene	Chr14:19138198-19195136 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019924	protein coding gene	Chr14:19954327-20008942 (+)
WSB/EiJ	MGP_WSBEiJ_G0020407	protein coding gene	Chr14:20516616-20571414 (+)

Human Ortholog

TASOR, transcription activation suppressor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TASOR, transcription activation suppressor
Synonyms

C3orf63, FAM208A, RAP140, se89-1, TASOR1
Links

HGNC:30314

NCBI Gene ID: 23272

neXtProt AC: NX_Q9UK61

UniProt: Q9UK61
Chr Location

3p14.3; chr3:56620132-56683265 (-) GRCh38

MGI Vertebrate Homology

Tasor stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TASOR
Gene Tree

Tasor

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Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (ENU)

2
Endonuclease-mediated

3
Gene trapped

17
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

93 strains or lines available

Mice homozygous for ENU mutations are not viable past gastrulation.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

13
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tasor

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All Sequences

50
RefSeq

11
UniProt

2
CCDS

CCDS49432.1

Ensembl

ENSMUSG00000040651 (Evidence)
NCBI Gene

218850

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040651	Ensembl Gene Model \| MGI Sequence Detail	54722	C57BL/6J	± kb
transcript	ENSMUST00000022450	Ensembl \| MGI Sequence Detail	7590	Not Applicable
polypeptide	ENSMUSP00000022450	Ensembl \| MGI Sequence Detail	1498	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032261 protein TASOR

(term hierarchy)
InterPro Domains

IPR046432 TASOR

IPR022188 TASOR, DUF3715
GlyGen

Q69ZR9 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 1

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MGD-MRK-34017, MGI:106325, MGI:3586544, MGI:6276248

Summaries

All 39

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 14
Earliest

J:34960 Chambers DM, et al., Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Genome Res. 1996 Aug;6(8):715-23
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tasor:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124753	Chr14:27150747-27150831 (+)	-2 bp
Tssr124754	Chr14:27150835-27150847 (+)	50 bp
Tssr124755	Chr14:27151928-27151932 (+)	1,139 bp
Tssr124756	Chr14:27153298-27153303 (+)	2,510 bp
Tssr124757	Chr14:27160789-27160793 (+)	10,000 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24