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Taf7l Gene Detail
Summary
  • Symbol
    Taf7l
  • Name
    TATA-box binding protein associated factor 7 like
  • Synonyms
    4933438I11Rik, Taf2q
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921719
    NCBI Gene: 74469
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:133360867-133377239 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 56.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    297 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921719
 protein coding gene ChrX:133360865-133377254 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036068
 protein coding gene ChrX:131641356-131657722 (-)
A/J MGP_AJ_G0036050
 protein coding gene ChrX:131056111-131072322 (-)
AKR/J MGP_AKRJ_G0035969
 protein coding gene ChrX:135263467-135279834 (-)
BALB/cJ MGP_BALBcJ_G0036041
 protein coding gene ChrX:129489082-129505503 (-)
C3H/HeJ MGP_C3HHeJ_G0035745
 protein coding gene ChrX:131716593-131732971 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036563
 protein coding gene ChrX:135513862-135535101 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033391
 protein coding gene ChrX:123241254-123257788 (-)
CAST/EiJ MGP_CASTEiJ_G0035032
 protein coding gene ChrX:112590670-112607017 (-)
CBA/J MGP_CBAJ_G0035722
 protein coding gene ChrX:139581576-139597901 (-)
DBA/2J MGP_DBA2J_G0035875
 protein coding gene ChrX:130371998-130388368 (-)
FVB/NJ MGP_FVBNJ_G0035817
 protein coding gene ChrX:129692409-129711584 (-)
LP/J MGP_LPJ_G0035968
 protein coding gene ChrX:132514388-132530793 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035845
 protein coding gene ChrX:146942634-146960126 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036592
 protein coding gene ChrX:131064455-131080824 (-)
PWK/PhJ MGP_PWKPhJ_G0034724
 protein coding gene ChrX:109531956-109548787 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034556
 protein coding gene ChrX:113225260-113244980 (-)
WSB/EiJ MGP_WSBEiJ_G0035169
 protein coding gene ChrX:129438113-129454487 (-)



Homology
more
  • Human Ortholog
    TAF7L, TATA-box binding protein associated factor 7 like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAF7L, TATA-box binding protein associated factor 7 like
  • Synonyms
    CT40, TAF2Q
  • Links
    NCBI Gene ID: 54457
    neXtProt AC: NX_Q5H9L4
    UniProt: Q5H9L4

  • Chr Location
    Xq22.1; chrX:101268253-101293083 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 4 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene causes male subfertility, oligozoospermia, teratozoospermia, athenozoospermia, abnormal seminiferous tubules, and reduced testis weight on congenic but not on mixed strain backgrounds. Decreased brown fat tissue amount and enhanced skeletal muscle formation are also observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    20
  • cDNA Data
    19
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009596 Ensembl Gene Model | MGI Sequence Detail 16373 C57BL/6J ±  kb
    transcript ENSMUST00000009740 Ensembl | MGI Sequence Detail 1933 Not Applicable  
    polypeptide ENSMUSP00000009740 Ensembl | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016034 transcription initiation factor TFIID subunit 7-like
      (term hierarchy)
    • InterPro Domains
      IPR006751 TAFII55 protein, conserved region
      IPR037817 Transcription initiation factor TFIID subunit 7
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 19
      Primer pair 4
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 12
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335376 Ling L, et al., Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man. Biol Reprod. 2022 Jul 25;107(1):157-167
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory