Batf2 MGI Mouse Gene Detail - MGI:1921731 - basic leucine zipper transcription factor, ATF-like 2

Symbol

Batf2
Name

basic leucine zipper transcription factor, ATF-like 2
Synonyms

4933430F08Rik

Feature Type

protein coding gene
IDs

MGI:1921731
NCBI Gene: 74481
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:6214424-6222506 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.34 cM, cytoband A
Mapping Data

2 experiments

SNPs within 2kb

334 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921731	protein coding gene	Chr19:6191013-6222506 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024752	protein coding gene	Chr19:3172663-3209205 (+)
A/J	MGP_AJ_G0024718	protein coding gene	Chr19:3004274-3035672 (+)
AKR/J	MGP_AKRJ_G0024691	protein coding gene	Chr19:3093449-3127571 (+)
BALB/cJ	MGP_BALBcJ_G0024718	protein coding gene	Chr19:3000916-3032832 (+)
C3H/HeJ	MGP_C3HHeJ_G0024486	protein coding gene	Chr19:3119245-3150673 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025164	protein coding gene	Chr19:3233711-3272531 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022598	protein coding gene	Chr19:2928947-2958942 (+)
CAST/EiJ	MGP_CASTEiJ_G0023958	protein coding gene	Chr19:3120640-3155900 (+)
CBA/J	MGP_CBAJ_G0024458	protein coding gene	Chr19:3399463-3430778 (+)
DBA/2J	MGP_DBA2J_G0024585	protein coding gene	Chr19:2992920-3024084 (+)
FVB/NJ	MGP_FVBNJ_G0024551	protein coding gene	Chr19:3002929-3036393 (+)
LP/J	MGP_LPJ_G0024671	protein coding gene	Chr19:3148745-3180021 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024580	protein coding gene	Chr19:3210460-3243234 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025212	protein coding gene	Chr19:3122447-3154280 (+)
PWK/PhJ	MGP_PWKPhJ_G0023704	protein coding gene	Chr19:3019009-3051872 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023509	protein coding gene	Chr19:3080981-3112333 (+)
WSB/EiJ	MGP_WSBEiJ_G0024020	protein coding gene	Chr19:3128853-3160613 (+)

Human Ortholog

BATF2, basic leucine zipper ATF-like transcription factor 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BATF2, basic leucine zipper ATF-like transcription factor 2
Synonyms

SARI
Links

HGNC:25163

NCBI Gene ID: 116071

neXtProt AC: NX_Q8N1L9

UniProt: Q8N1L9
Chr Location

11q13.1; chr11:64987945-64997018 (-) GRCh38

MGI Vertebrate Homology

Batf2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BATF2
Gene Tree

Batf2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

3
Gene trapped

3
Targeted

4
Find Mice (IMSR)

15 strains or lines available

Mice homozygous for a knock-out allele exhibit increased susceptibility to parasitic infection induced morbidity/mortality.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

851
Tissues

99
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

8
UniProt

1
CCDS

CCDS29497.1, CCDS89321.1

Ensembl

ENSMUSG00000039699 (Evidence)
NCBI Gene

74481

			Length	Strain/Species	Flank
genomic	74481	NCBI Gene Model \| MGI Sequence Detail	8083	C57BL/6J	± kb
transcript	NM_001379529	RefSeq \| MGI Sequence Detail	2006	C57BL/6
polypeptide	Q8R1H8	UniProt \| EBI \| MGI Sequence Detail	277	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004655 basic leucine zipper transcriptional factor ATF-like 2

(term hierarchy)
InterPro Domains

IPR000837 AP-1 transcription factor

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

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All nucleic 8

cDNA 8

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:351161 Zong Y, et al., The role of BATF2 deficiency in immune microenvironment rearrangement in cervical cancer - New biomarker benefiting from combination of radiotherapy and immunotherapy. Int Immunopharmacol. 2024 Jan 5;126:111199

TSS for Batf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154583	Chr19:6214463-6214476 (+)	46 bp
Tssr154584	Chr19:6214480-6214491 (+)	62 bp
Tssr154585	Chr19:6214508-6214541 (+)	101 bp
Tssr154586	Chr19:6215768-6215781 (+)	1,351 bp
Tssr154587	Chr19:6215796-6215807 (+)	1,378 bp
Tssr154588	Chr19:6221987-6221994 (+)	7,567 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24