Cyp2j9 MGI Mouse Gene Detail - MGI:1921769 - cytochrome P450, family 2, subfamily j, polypeptide 9

Symbol

Cyp2j9
Name

cytochrome P450, family 2, subfamily j, polypeptide 9
Synonyms

8430417E17Rik

Feature Type

protein coding gene
IDs

MGI:1921769
NCBI Gene: 74519
Member of

Cyp2j cluster
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr4:96456666-96479815 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 44.66 cM, cytoband C5
Mapping Data

2 experiments

SNPs within 2kb

689 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921769	protein coding gene	Chr4:96456661-96480748 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028465	protein coding gene	Chr4:96667393-96691846 (-)
A/J	MGP_AJ_G0028428	protein coding gene	Chr4:93263290-93286344 (-)
AKR/J	MGP_AKRJ_G0028375	protein coding gene	Chr4:95544929-95568037 (-)
BALB/cJ	MGP_BALBcJ_G0028446	protein coding gene	Chr4:93535444-93558492 (-)
C3H/HeJ	MGP_C3HHeJ_G0028159	protein coding gene	Chr4:96348632-96371650 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028885	protein coding gene	Chr4:100352604-100382456 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026177	protein coding gene	Chr4:88748249-88776624 (-)
CAST/EiJ	MGP_CASTEiJ_G0027599	protein coding gene	Chr4:94142609-94167806 (-)
CBA/J	MGP_CBAJ_G0028128	protein coding gene	Chr4:103400689-103425935 (-)
DBA/2J	MGP_DBA2J_G0028278	protein coding gene	Chr4:93070448-93093622 (-)
FVB/NJ	MGP_FVBNJ_G0028245	protein coding gene	Chr4:91922789-91945800 (-)
LP/J	MGP_LPJ_G0028378	protein coding gene	Chr4:96991374-97014927 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028273	protein coding gene	Chr4:109170314-109193754 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028923	protein coding gene	Chr4:95803949-95827736 (-)
PWK/PhJ	MGP_PWKPhJ_G0027324	protein coding gene	Chr4:91180388-91203791 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027145	protein coding gene	Chr4:93236917-93261326 (-)
WSB/EiJ	MGP_WSBEiJ_G0027677	protein coding gene	Chr4:95920408-95944466 (-)

Human Ortholog

CYP2J2, cytochrome P450 family 2 subfamily J member 2

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP2J2, cytochrome P450 family 2 subfamily J member 2
Synonyms

CPJ2, CYPIIJ2
Links

HGNC:2634

NCBI Gene ID: 1573

neXtProt AC: NX_P51589

UniProt: P51589
Chr Location

1p32.1; chr1:59893308-59969212 (-) GRCh38

MGI Vertebrate Homology

Cyp2j9 stringent orthology
1 human;1 mouse;1 rat;6 zebrafish
HCOP

vertebrate homology predictions: CYP2J2
Gene Tree

Cyp2j9

Diseases

5 with human CYP2J2 associations

				Human Disease	Mouse Models
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				pulmonary hypertension IDs pulmonary hypertension DOID:6432 ICD10CM:I27.20 MESH:D006976 NCI:C3120 UMLS_CUI:C0020542
				renal fibrosis IDs renal fibrosis DOID:0050855
				renal hypertension IDs renal hypertension DOID:1073 MESH:D006977 NCI:C3121 UMLS_CUI:C0020544

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

8 phenotype references

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Cyp2j9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

less

All GO Annotations

15
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

893
Tissues

111
cDNA Data

8
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

39
RefSeq

10
UniProt

2
CCDS

CCDS18370.1

Ensembl

ENSMUSG00000015224 (Evidence)
NCBI Gene

74519

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015224	Ensembl Gene Model \| MGI Sequence Detail	23150	C57BL/6J	± kb
transcript	ENSMUST00000055693	Ensembl \| MGI Sequence Detail	2037	Not Applicable
polypeptide	ENSMUSP00000050464	Ensembl \| MGI Sequence Detail	502	Not Applicable

less

UniProt

2 Sequences
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR002401 Cytochrome P450, E-class, group I

IPR008071 Cytochrome P450, E-class, group I, CYP2J-like

IPR050182 Cytochrome P450 family 2

IPR036396 Cytochrome P450 superfamily

less

All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:261864 Beloiartsev A, et al., Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j. Am J Respir Cell Mol Biol. 2015 May;52(5):563-70

TSS for Cyp2j9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42485	Chr4:96479792-96479831 (-)	3 bp
Tssr42484	Chr4:96479712-96479742 (-)	88 bp
Tssr42483	Chr4:96479642-96479691 (-)	148 bp
Tssr42482	Chr4:96479605-96479632 (-)	196 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24