Morc2a MGI Mouse Gene Detail - MGI:1921772

Symbol

Morc2a
Name

microrchidia 2A
Synonyms

8430403M08Rik, Zcwcc1

Feature Type

protein coding gene
IDs

MGI:1921772
NCBI Gene: 74522
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:3599191-3640477 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.56 cM
Mapping Data

2 experiments

SNPs within 2kb

719 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921772	protein coding gene	Chr11:3599132-3640477 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017962	protein coding gene	Chr11:537265-581023 (+)
A/J	MGP_AJ_G0017935	protein coding gene	Chr11:574370-618654 (+)
AKR/J	MGP_AKRJ_G0017899	protein coding gene	Chr11:595499-636446 (+)
BALB/cJ	MGP_BALBcJ_G0017903	protein coding gene	Chr11:541713-582693 (+)
C3H/HeJ	MGP_C3HHeJ_G0017716	protein coding gene	Chr11:526909-568542 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018356	protein coding gene	Chr11:612955-653849 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016015	protein coding gene	Chr11:477226-518854 (+)
CAST/EiJ	MGP_CASTEiJ_G0017278	protein coding gene	Chr11:491686-536318 (+)
CBA/J	MGP_CBAJ_G0017691	protein coding gene	Chr11:785734-826736 (+)
DBA/2J	MGP_DBA2J_G0017802	protein coding gene	Chr11:487898-528871 (+)
FVB/NJ	MGP_FVBNJ_G0017793	protein coding gene	Chr11:518591-560596 (+)
LP/J	MGP_LPJ_G0017872	protein coding gene	Chr11:626015-669211 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017819	protein coding gene	Chr11:533732-576190 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018395	protein coding gene	Chr11:609612-653319 (+)
PWK/PhJ	MGP_PWKPhJ_G0017059	protein coding gene	Chr11:474874-517465 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016855	protein coding gene	Chr11:564886-609957 (+)
WSB/EiJ	MGP_WSBEiJ_G0017332	protein coding gene	Chr11:485425-527440 (+)

Human Ortholog

MORC2, MORC family CW-type zinc finger 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MORC2, MORC family CW-type zinc finger 2
Synonyms

CMT2Z, DIGFAN, ZCW3, ZCWCC1
Links

HGNC:23573

NCBI Gene ID: 22880

neXtProt AC: NX_Q9Y6X9

UniProt: Q9Y6X9
Chr Location

22q12.2; chr22:30925130-30968774 (-) GRCh38

MGI Vertebrate Homology

Morc2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MORC2
Gene Tree

Morc2a

Diseases

1 with Morc2a mouse models; 1 with human MORC2 associations

Human Disease

Mouse Models

Charcot-Marie-Tooth disease axonal type 2Z

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

170 phenotypes from 5 alleles in 5 genetic backgrounds
5 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

4
Gene trapped

8
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality around E13.5 and decreased embryo size. Mice homozygous for a null allele activated in neurons exhibit increased brain size, altered brain architecture, and behavioral changes. Heterozygosity for the p.S87L mutation is partially prenatal lethal and leads to Charcot-Marie-Tooth disease-like neuropathies.

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All GO Annotations

41
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

18
cDNA Data

7
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN morc2

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All Sequences

51
RefSeq

12
UniProt

3
CCDS

CCDS48741.1

Ensembl

ENSMUSG00000034543 (Evidence)
NCBI Gene

74522

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034543	Ensembl Gene Model \| MGI Sequence Detail	41287	C57BL/6J	± kb
transcript	ENSMUST00000096441	Ensembl \| MGI Sequence Detail	5656	Not Applicable
polypeptide	ENSMUSP00000094176	Ensembl \| MGI Sequence Detail	1030	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032615 ATPase MORC2

(term hierarchy)
EC

3.6.1.-
InterPro Domains

IPR036890 Histidine kinase/HSP90-like ATPase superfamily

IPR041006 Morc, S5 domain 2-like

IPR011124 Zinc finger, CW-type
GlyGen

Q69ZX6 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 6

Diseases 1

Gene Ontology 8

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75

TSS for Morc2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100064	Chr11:3598781-3598793 (+)	-404 bp
Tssr100065	Chr11:3599198-3599295 (+)	56 bp
Tssr100066	Chr11:3605693-3605712 (+)	6,512 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24