Shpk MGI Mouse Gene Detail - MGI:1921887

Symbol

Shpk
Name

sedoheptulokinase
Synonyms

4930431K22Rik, Carkl

Feature Type

protein coding gene
IDs

MGI:1921887
NCBI Gene: 74637
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:73090286-73115337 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.25 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

159 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921887	protein coding gene	Chr11:73090153-73115337 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018657	protein coding gene	Chr11:73880703-73907070 (+)
A/J	MGP_AJ_G0018625	protein coding gene	Chr11:71107901-71134278 (+)
AKR/J	MGP_AKRJ_G0018594	protein coding gene	Chr11:73282350-73307219 (+)
BALB/cJ	MGP_BALBcJ_G0018597	protein coding gene	Chr11:71409836-71434653 (+)
C3H/HeJ	MGP_C3HHeJ_G0018410	protein coding gene	Chr11:73231807-73257669 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019048	protein coding gene	Chr11:76130836-76156158 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016691	protein coding gene	Chr11:67912539-67938416 (+)
CAST/EiJ	MGP_CASTEiJ_G0017965	protein coding gene	Chr11:73615279-73642763 (+)
CBA/J	MGP_CBAJ_G0018382	protein coding gene	Chr11:79479074-79503943 (+)
DBA/2J	MGP_DBA2J_G0018491	protein coding gene	Chr11:70734970-70759849 (+)
FVB/NJ	MGP_FVBNJ_G0018482	protein coding gene	Chr11:70280897-70305632 (+)
LP/J	MGP_LPJ_G0018562	protein coding gene	Chr11:74396008-74421923 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018505	protein coding gene	Chr11:79994067-80019850 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019090	protein coding gene	Chr11:73462784-73487726 (+)
PWK/PhJ	MGP_PWKPhJ_G0017738	protein coding gene	Chr11:71375436-71401974 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017528	protein coding gene	Chr11:73176943-73204911 (+)
WSB/EiJ	MGP_WSBEiJ_G0018019	protein coding gene	Chr11:73213282-73239273 (+)

Human Ortholog

SHPK, sedoheptulokinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SHPK, sedoheptulokinase
Synonyms

CARKL, SHK
Links

HGNC:1492

NCBI Gene ID: 23729

neXtProt AC: NX_Q9UHJ6

UniProt: Q9UHJ6
Chr Location

17p13.2; chr17:3608240-3636250 (-) GRCh38

MGI Vertebrate Homology

Shpk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SHPK
Gene Tree

Shpk

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

4
Genomic Mutations

2 involving Shpk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show pentose phosphate pathway dysregulation in the liver and an increase in urinary sedoheptulose and erythritol levels.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

1
cDNA Data

33
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase shpk

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All Sequences

39
RefSeq

3
UniProt

2
CCDS

CCDS25002.1

Ensembl

ENSMUSG00000005951 (Evidence)
NCBI Gene

74637

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005951	Ensembl Gene Model \| MGI Sequence Detail	25052	C57BL/6J	± kb
transcript	ENSMUST00000006105	Ensembl \| MGI Sequence Detail	2808	Not Applicable
polypeptide	ENSMUSP00000006105	Ensembl \| MGI Sequence Detail	476	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014851 sedoheptulokinase

(term hierarchy)
EC

2.7.1.14
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR018484 Carbohydrate kinase FGGY, N-terminal

IPR050406 FGGY Carbohydrate Kinase

IPR042027 Sedoheptulokinase

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All nucleic 33

cDNA 33

Microarray probesets 3

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MGI:2144081, MGI:2144522

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357415 Gallerand A, et al., Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice. Nat Commun. 2024 Oct 19;15(1):9027

TSS for Shpk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102890	Chr11:73090271-73090326 (+)	13 bp
Tssr102891	Chr11:73104217-73104225 (+)	13,935 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24