Drc3 MGI Mouse Gene Detail - MGI:1921915 - dynein regulatory complex subunit 3

Symbol

Drc3
Name

dynein regulatory complex subunit 3
Synonyms

4930449E07Rik, Lrrc48, m6Bei

Feature Type

protein coding gene
IDs

MGI:1921915
NCBI Gene: 74665
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:60244155-60285167 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.81 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

1142 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921915	protein coding gene	Chr11:60243063-60285168 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018415	protein coding gene	Chr11:60227813-60271473 (+)
A/J	MGP_AJ_G0018384	protein coding gene	Chr11:57943400-57984537 (+)
AKR/J	MGP_AKRJ_G0018354	protein coding gene	Chr11:59878660-59919791 (+)
BALB/cJ	MGP_BALBcJ_G0018355	protein coding gene	Chr11:58286494-58327472 (+)
C3H/HeJ	MGP_C3HHeJ_G0018168	protein coding gene	Chr11:59752704-59796336 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018807	protein coding gene	Chr11:62129561-62173198 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016453	protein coding gene	Chr11:55177533-55219344 (+)
CAST/EiJ	MGP_CASTEiJ_G0017725	protein coding gene	Chr11:59894574-59937631 (+)
CBA/J	MGP_CBAJ_G0018142	protein coding gene	Chr11:64860996-64902560 (+)
DBA/2J	MGP_DBA2J_G0018251	protein coding gene	Chr11:57597993-57640198 (+)
FVB/NJ	MGP_FVBNJ_G0018242	protein coding gene	Chr11:57265593-57307191 (+)
LP/J	MGP_LPJ_G0018324	protein coding gene	Chr11:60830817-60875558 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018266	protein coding gene	Chr11:65917282-65961869 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018848	protein coding gene	Chr11:59906571-59950591 (+)
PWK/PhJ	MGP_PWKPhJ_G0017496	protein coding gene	Chr11:58202908-58246074 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017288	protein coding gene	Chr11:59710377-59751742 (+)
WSB/EiJ	MGP_WSBEiJ_G0017776	protein coding gene	Chr11:59585907-59628896 (+)

Human Ortholog

DRC3, dynein regulatory complex subunit 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DRC3, dynein regulatory complex subunit 3
Synonyms

CFAP134, LRRC48
Links

HGNC:25384

NCBI Gene ID: 83450

neXtProt AC: NX_Q9H069

UniProt: Q9H069
Chr Location

17p11.2; chr17:17972813-18016889 (+) GRCh38

MGI Vertebrate Homology

Drc3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DRC3
Gene Tree

Drc3

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References

3 with disease annotations

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Phenotype Summary

6 phenotypes from multigenic genotypes
20 phenotype references

All Mutations and Alleles

21
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

14
Targeted

3
Genomic Mutations

4 involving Drc3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

17
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase drc3

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All Sequences

43
RefSeq

6
UniProt

4
CCDS

CCDS36172.1

Ensembl

ENSMUSG00000056598 (Evidence)
NCBI Gene

74665

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056598	Ensembl Gene Model \| MGI Sequence Detail	41013	C57BL/6J	± kb
transcript	ENSMUST00000108723	Ensembl \| MGI Sequence Detail	1917	Not Applicable
polypeptide	ENSMUSP00000104363	Ensembl \| MGI Sequence Detail	523	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031201 dynein regulatory complex subunit 3

(term hierarchy)
InterPro Domains

IPR050576 Ciliary and flagellar integrity-associated protein

IPR001611 Leucine-rich repeat

IPR025875 Leucine rich repeat 4

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

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All nucleic 14

cDNA 14

Microarray probesets 4

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MGI:5505443

Summaries

All 47

Developmental Gene Expression 3

Diseases 3

Gene Ontology 5

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:284740 Morohoshi A, et al., Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. PLoS Genet. 2020 Jan;16(1):e1008585

TSS for Drc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101882	Chr11:60243902-60243916 (+)	-246 bp
Tssr101883	Chr11:60244150-60244234 (+)	37 bp
Tssr101884	Chr11:60279016-60279039 (+)	34,873 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24