Rhoh MGI Mouse Gene Detail - MGI:1921984 - ras homolog family member H

Symbol

Rhoh
Name

ras homolog family member H
Synonyms

5830400A04Rik, Arhh

Feature Type

protein coding gene
IDs

MGI:1921984
NCBI Gene: 74734
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr5:66018556-66054043 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 33.80 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

1219 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921984	protein coding gene	Chr5:66018092-66054043 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029584	protein coding gene	Chr5:65561599-65596878 (+)
A/J	MGP_AJ_G0029552	protein coding gene	Chr5:63097510-63133483 (+)
AKR/J	MGP_AKRJ_G0029500	protein coding gene	Chr5:65121076-65158435 (+)
BALB/cJ	MGP_BALBcJ_G0029561	protein coding gene	Chr5:63790224-63825875 (+)
C3H/HeJ	MGP_C3HHeJ_G0029284	protein coding gene	Chr5:65453170-65488547 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030015	protein coding gene	Chr5:68244216-68281796 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027255	protein coding gene	Chr5:59161396-59197772 (+)
CAST/EiJ	MGP_CASTEiJ_G0028692	protein coding gene	Chr5:64546899-64584715 (+)
CBA/J	MGP_CBAJ_G0029253	protein coding gene	Chr5:70471730-70509948 (+)
DBA/2J	MGP_DBA2J_G0029399	protein coding gene	Chr5:63132916-63168605 (+)
FVB/NJ	MGP_FVBNJ_G0029359	protein coding gene	Chr5:62298629-62333888 (+)
LP/J	MGP_LPJ_G0029484	protein coding gene	Chr5:66044877-66082253 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029387	protein coding gene	Chr5:73322210-73359409 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030048	protein coding gene	Chr5:64772975-64811949 (+)
PWK/PhJ	MGP_PWKPhJ_G0028416	protein coding gene	Chr5:62108752-62142692 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028250	protein coding gene	Chr5:64116225-64152835 (+)
WSB/EiJ	MGP_WSBEiJ_G0028772	protein coding gene	Chr5:65000768-65037732 (+)

Human Ortholog

RHOH, ras homolog family member H

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RHOH, ras homolog family member H
Synonyms

ARHH, TTF
Links

HGNC:686

NCBI Gene ID: 399

neXtProt AC: NX_Q15669

UniProt: Q15669
Chr Location

4p14; chr4:40191011-40246967 (+) GRCh38

MGI Vertebrate Homology

Rhoh stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RHOH
Gene Tree

Rhoh

Diseases

1 with human RHOH associations

				Human Disease	Mouse Models
				epidermodysplasia verruciformis IDs epidermodysplasia verruciformis DOID:13777 MESH:D004819 NCI:C126877 OMIM:PS226400 ORDO:302 UMLS_CUI:C0014522

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

25 phenotypes from 3 alleles in 3 genetic backgrounds
6 phenotypes from multigenic genotypes
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Spontaneous

1
Targeted

6
Genomic Mutations

4 involving Rhoh
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display abnormalities in the differentiation of T cells and mast cell physiology.

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

9
cDNA Data

39
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RHOH

Xenbase rhoh

ZFIN rhoh

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All Sequences

49
RefSeq

8
UniProt

3
CCDS

CCDS39100.1

Ensembl

ENSMUSG00000029204 (Evidence)
NCBI Gene

74734

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029204	Ensembl Gene Model \| MGI Sequence Detail	35488	C57BL/6J	± kb
transcript	ENSMUST00000031106	Ensembl \| MGI Sequence Detail	5093	Not Applicable
polypeptide	ENSMUSP00000031106	Ensembl \| MGI Sequence Detail	191	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013982 Rho-related GTP-binding protein RhoH

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR003578 Small GTPase Rho

IPR005225 Small GTP-binding protein domain

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All nucleic 40

cDNA 40

Microarray probesets 3

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MGI:2141048

Summaries

All 66

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 38
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rhoh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1495	Chr5:66018090-66018102 (+)	-460 bp
Tssr46494	Chr5:66018281-66018319 (+)	-256 bp
Tssr46495	Chr5:66018478-66018492 (+)	-71 bp
Tssr46496	Chr5:66018504-66018515 (+)	-46 bp
Tssr46497	Chr5:66018555-66018580 (+)	12 bp
Tssr46498	Chr5:66018604-66018661 (+)	77 bp
Tssr46499	Chr5:66018701-66018711 (+)	150 bp
Tssr46500	Chr5:66019993-66019996 (+)	1,439 bp
Tssr46501	Chr5:66020611-66020637 (+)	2,068 bp
Tssr46502	Chr5:66020906-66020993 (+)	2,394 bp
Tssr46503	Chr5:66020996-66020999 (+)	2,442 bp
Tssr46504	Chr5:66021118-66021138 (+)	2,572 bp
Tssr46505	Chr5:66025599-66025613 (+)	7,050 bp
Tssr46506	Chr5:66043076-66043080 (+)	24,522 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24