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Ralgps1 Gene Detail
Summary
  • Symbol
    Ralgps1
  • Name
    Ral GEF with PH domain and SH3 binding motif 1
  • Synonyms
    5830418G11Rik, mKIAA0351, RALGEF2, RALGPS1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922008
    NCBI Gene: 241308
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:33023429-33261498 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4505 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922008
 protein coding gene Chr2:33023429-33261569 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025631
 protein coding gene Chr2:31644144-31888937 (-)
A/J MGP_AJ_G0025608
 protein coding gene Chr2:30294205-30534932 (-)
AKR/J MGP_AKRJ_G0025578
 protein coding gene Chr2:31374600-31619462 (-)
BALB/cJ MGP_BALBcJ_G0025605
 protein coding gene Chr2:30414522-30622412 (-)
C3H/HeJ MGP_C3HHeJ_G0025365
 protein coding gene Chr2:31267486-31476408 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026049
 protein coding gene Chr2:32586209-32834333 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023458
 protein coding gene Chr2:29023466-29236293 (-)
CAST/EiJ MGP_CASTEiJ_G0024827
 protein coding gene Chr2:31233756-31477216 (-)
CBA/J MGP_CBAJ_G0025343
 protein coding gene Chr2:33835076-34085831 (-)
DBA/2J MGP_DBA2J_G0025476
 protein coding gene Chr2:30057267-30296457 (-)
FVB/NJ MGP_FVBNJ_G0025438
 protein coding gene Chr2:29950171-30196255 (-)
LP/J MGP_LPJ_G0025562
 protein coding gene Chr2:31531959-31786503 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025469
 protein coding gene Chr2:33435151-33649937 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026107
 protein coding gene Chr2:31258692-31503666 (-)
PWK/PhJ MGP_PWKPhJ_G0024575
 protein coding gene Chr2:29973539-30214984 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024375
 protein coding gene Chr2:31420077-31678311 (-)
WSB/EiJ MGP_WSBEiJ_G0024896
 protein coding gene Chr2:31445698-31687277 (-)



Homology
more
  • Human Ortholog
    RALGPS1, Ral GEF with PH domain and SH3 binding motif 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RALGPS1, Ral GEF with PH domain and SH3 binding motif 1
  • Synonyms
    RALGEF2, RALGPS1A
  • Links
    NCBI Gene ID: 9649
    neXtProt AC: NX_Q5JS13
    UniProt: Q5JS13

  • Chr Location
    9q33.3; chr9:126914774-127223166 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    77
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038831 Ensembl Gene Model | MGI Sequence Detail 238070 C57BL/6J ±  kb
    transcript ENSMUST00000091039 Ensembl | MGI Sequence Detail 2738 Not Applicable  
    polypeptide ENSMUSP00000088563 Ensembl | MGI Sequence Detail 585 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013699 Ras-specific guanine nucleotide-releasing factor RalGPS1
      (term hierarchy)
    • PDB
      2DTC
    • InterPro Domains
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR008937 Ras-like guanine nucleotide exchange factor
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 2
      cDNA 78

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139099, MGI:2139101
    References
    more
    • Summaries
      All 35
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory