Rrp7a Gene Detail

Summary

• Symbol
  Rrp7a
• Name
  ribosomal RNA processing 7 homolog A
• Synonyms
  1110014J01Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1922028
  NCBI Gene: 74778
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr15:83000047-83007002 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 39.40 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  256 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922028	protein coding gene	Chr15:82997634-83007002 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022158	protein coding gene	Chr15:83777035-83786383 (-)
A/J	MGP_AJ_G0022117	protein coding gene	Chr15:80721060-80727087 (-)
AKR/J	MGP_AKRJ_G0022092	protein coding gene	Chr15:83038478-83049557 (-)
BALB/cJ	MGP_BALBcJ_G0022123	protein coding gene	Chr15:80861466-80867806 (-)
C3H/HeJ	MGP_C3HHeJ_G0021893	protein coding gene	Chr15:83035383-83046305 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022568	protein coding gene	Chr15:87009687-87022352 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020092	protein coding gene	Chr15:77113169-77122844 (-)
CAST/EiJ	MGP_CASTEiJ_G0021415	protein coding gene	Chr15:83779048-83788342 (-)
CBA/J	MGP_CBAJ_G0021860	protein coding gene	Chr15:89755084-89766343 (-)
DBA/2J	MGP_DBA2J_G0021987	protein coding gene	Chr15:80219824-80229682 (-)
FVB/NJ	MGP_FVBNJ_G0021966	protein coding gene	Chr15:79253253-79265144 (-)
LP/J	MGP_LPJ_G0022058	protein coding gene	Chr15:83952049-83961282 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021986	protein coding gene	Chr15:94687520-94699745 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022583	protein coding gene	Chr15:83068203-83088221 (-)
PWK/PhJ	MGP_PWKPhJ_G0021156	protein coding gene	Chr15:80192256-80202765 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020990	protein coding gene	Chr15:82798262-82807536 (-)
WSB/EiJ	MGP_WSBEiJ_G0021464	protein coding gene	Chr15:83576240-83582490 (-)

Homology

• Human Ortholog
  RRP7A, ribosomal RNA processing 7 homolog A

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  RRP7A, ribosomal RNA processing 7 homolog A
  
• Synonyms
  BK126B4.3, CGI-96, MCPH28, Rrp7
• Links
  HGNC:24286

  NCBI Gene ID: 27341

  neXtProt AC: NX_Q9Y3A4

  UniProt: Q9Y3A4

  
  
• Chr Location
  22q13.2; chr22:42508344-42519796 (-)  GRCh38

---

• Human Ortholog
  RRP7BP, ribosomal RNA processing 7 homolog B, pseudogene
  
• Synonyms
  dJ222E13.2, RRP7B
• Links
  HGNC:30454

  NCBI Gene ID: 91695

  UniProt: Q9NSQ0

  
  
• Chr Location
  22q13.2; chr22:42555212-42582039 (-)  GRCh38

---

• MGI Vertebrate Homology
  Rrp7a stringent orthology
  2 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: RRP7A, RRP7BP
• Gene Tree
  Rrp7a
  

Human Diseases

• Diseases
  1 with human RRP7A associations

				Human Disease	Mouse Models
				primary autosomal recessive microcephaly IDs primary autosomal recessive microcephaly       DOID:0070296 OMIM:PS251200 ORDO:2512

Click on a disease name to see all genes associated with that disease.

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  22 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Radiation induced
  2
• Targeted
  2
• Genomic Mutations
  3 involving Rrp7a
• Incidental Mutations
  APF
• Find Mice (IMSR)
  9 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  20
• GO References
  7

Expression

• Assay Results
  713
• Tissues
  7
• cDNA Data
  14
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase rrp7a
  ZFIN rrp7a

Sequences &
Gene Models

• All Sequences
  69
• RefSeq
  4
• UniProt
  6
• CCDS
  CCDS27696.1

• Ensembl
  ENSMUSG00000018040 (Evidence)
• NCBI Gene
  74778

Representative Sequences			Length	Strain/Species
genomic	74778	NCBI Gene Model | MGI Sequence Detail	6956	C57BL/6J
transcript	NM_029101	RefSeq | MGI Sequence Detail	1965	C57BL/6
polypeptide	Q9D1C9	UniProt | EBI | MGI Sequence Detail	280	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000014313 ribosomal RNA-processing protein 7 homolog A
  (term hierarchy)
• InterPro Domains
  IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
  IPR040446 Ribosomal RNA-processing protein 7
  IPR024326 Ribosomal RNA-processing protein 7, C-terminal domain
  IPR035979 RNA-binding domain superfamily
  IPR034890 Rrp7A, RNA recognition motif
  IPR040447 Rrp7, RRM-like N-terminal domain

Molecular
Reagents

• All nucleic 15

  cDNA 14

  Primer pair 1

  
  

  Microarray probesets 6

Other
Accession IDs

MGI:2142919

References

• Summaries
  All 50

  Developmental Gene Expression 1

  Diseases 1

  Gene Ontology 7

  Phenotypes 22
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Rrp7a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135619	Chr15:83006957-83006983 (-)	32 bp
Tssr135618	Chr15:83006934-83006947 (-)	61 bp
Tssr135617	Chr15:83006289-83006332 (-)	691 bp