Tpr Gene Detail

Summary

• Symbol
  Tpr
• Name
  translocated promoter region, nuclear basket protein
• Synonyms
  2610029M07Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1922066
  NCBI Gene: 108989
• Alliance
  gene page
• Transcription Start Sites
  37 TSS

Location &
Maps

• Sequence Map
  Chr1:150268589-150325686 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 63.84 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  1414 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922066	protein coding gene	Chr1:150268544-150325686 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016576	protein coding gene	Chr1:155040706-155097762 (+)
A/J	MGP_AJ_G0016558	protein coding gene	Chr1:148793256-148851412 (+)
AKR/J	MGP_AKRJ_G0016523	protein coding gene	Chr1:153341248-153400002 (+)
BALB/cJ	MGP_BALBcJ_G0016518	protein coding gene	Chr1:149322347-149379387 (+)
C3H/HeJ	MGP_C3HHeJ_G0016343	protein coding gene	Chr1:153523798-153580945 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016979	protein coding gene	Chr1:160415176-160475323 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014688	protein coding gene	Chr1:141148729-141208272 (+)
CAST/EiJ	MGP_CASTEiJ_G0015922	protein coding gene	Chr1:152914626-152977519 (+)
CBA/J	MGP_CBAJ_G0016317	protein coding gene	Chr1:166085430-166142555 (+)
DBA/2J	MGP_DBA2J_G0016423	protein coding gene	Chr1:147847553-147905093 (+)
FVB/NJ	MGP_FVBNJ_G0016421	protein coding gene	Chr1:146301845-146359132 (+)
LP/J	MGP_LPJ_G0016494	protein coding gene	Chr1:156073425-156131607 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016447	protein coding gene	Chr1:173776268-173837785 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017015	protein coding gene	Chr1:153154514-153211904 (+)
PWK/PhJ	MGP_PWKPhJ_G0015708	protein coding gene	Chr1:146761378-146821360 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015495	protein coding gene	Chr1:151932264-151998312 (+)
WSB/EiJ	MGP_WSBEiJ_G0015985	protein coding gene	Chr1:153228000-153286783 (+)

Homology

• Human Ortholog
  TPR, translocated promoter region, nuclear basket protein

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TPR, translocated promoter region, nuclear basket protein
  
• Synonyms
  MRT79
• Links
  HGNC:12017

  NCBI Gene ID: 7175

  neXtProt AC: NX_P12270

  UniProt: P12270

  
  
• Chr Location
  1q31.1; chr1:186311652-186375693 (-)  GRCh38

---

• MGI Vertebrate Homology
  Tpr stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: TPR
• Gene Tree
  Tpr
  

Human Diseases

• Diseases
  1 with human TPR associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder IDs autosomal recessive intellectual developmental disorder       DOID:0060308 OMIM:PS249500 ORDO:88616

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  18 phenotype references
  

• All Mutations and Alleles
  34
• Chemically induced (other)
  2
• Endonuclease-mediated
  3
• Gene trapped
  24
• Targeted
  5
• Genomic Mutations
  2 involving Tpr
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  123 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  104
• GO References
  12

Expression

• Assay Results
  809
• Tissues
  18
• cDNA Data
  22
• Literature Summary
  6

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA TPR
  Xenbase tpr
  ZFIN tprb

Sequences &
Gene Models

• All Sequences
  88
• RefSeq
  4
• UniProt
  14
• CCDS
  CCDS35734.2

• Ensembl
  ENSMUSG00000006005 (Evidence)
• NCBI Gene
  108989

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000006005	Ensembl Gene Model | MGI Sequence Detail	57098	C57BL/6J
transcript	ENSMUST00000124973	Ensembl | MGI Sequence Detail	7430	Not Applicable
polypeptide	ENSMUSP00000117616	Ensembl | MGI Sequence Detail	2431	Not Applicable

Protein
Information

• UniProt
  14 Sequences
• Protein Ontology
  PR:000016588 nucleoprotein TPR
  (term hierarchy)
• InterPro Domains
  IPR012929 Nucleoprotein TPR/MLP1
• GlyGen
  F6ZDS4 3 sites, 1 O-linked glycan (3 sites)

Molecular
Reagents

• All nucleic 23

  cDNA 23

  
  

  Microarray probesets 8

Other
Accession IDs

MGI:2138665

References

• Summaries
  All 55

  Developmental Gene Expression 6

  Gene Ontology 12

  Phenotypes 18
• Earliest
  J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tpr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9328	Chr1:150268545-150268600 (+)	-16 bp
Tssr9329	Chr1:150268615-150268628 (+)	33 bp
Tssr9330	Chr1:150269004-150269016 (+)	421 bp
Tssr9331	Chr1:150269021-150269162 (+)	503 bp
Tssr9332	Chr1:150269190-150269251 (+)	632 bp
Tssr9333	Chr1:150269350-150269361 (+)	767 bp
Tssr9334	Chr1:150270991-150271005 (+)	2,409 bp
Tssr9335	Chr1:150271011-150271026 (+)	2,430 bp
Tssr9336	Chr1:150279393-150279408 (+)	10,812 bp
Tssr9337	Chr1:150279712-150279725 (+)	11,130 bp
Tssr9338	Chr1:150283075-150283087 (+)	14,492 bp
Tssr9339	Chr1:150283094-150283114 (+)	14,515 bp
Tssr9340	Chr1:150283122-150283133 (+)	14,539 bp
Tssr9341	Chr1:150283238-150283250 (+)	14,655 bp
Tssr9342	Chr1:150283257-150283280 (+)	14,680 bp
Tssr9343	Chr1:150283281-150283299 (+)	14,701 bp
Tssr9344	Chr1:150290241-150290261 (+)	21,662 bp
Tssr9345	Chr1:150290265-150290278 (+)	21,683 bp
Tssr9346	Chr1:150293224-150293239 (+)	24,643 bp
Tssr9347	Chr1:150297436-150297458 (+)	28,858 bp
Tssr9348	Chr1:150297462-150297473 (+)	28,879 bp
Tssr9349	Chr1:150299268-150299290 (+)	30,690 bp
Tssr9350	Chr1:150299291-150299308 (+)	30,711 bp
Tssr9351	Chr1:150299542-150299557 (+)	30,961 bp
Tssr9352	Chr1:150299628-150299648 (+)	31,049 bp
Tssr9353	Chr1:150299694-150299705 (+)	31,111 bp
Tssr9354	Chr1:150300437-150300483 (+)	31,871 bp
Tssr9355	Chr1:150302614-150302645 (+)	34,041 bp
Tssr9356	Chr1:150305459-150305467 (+)	36,874 bp
Tssr9357	Chr1:150306378-150306392 (+)	37,796 bp
Tssr9358	Chr1:150306973-150306992 (+)	38,394 bp
Tssr9359	Chr1:150308212-150308223 (+)	39,629 bp
Tssr9360	Chr1:150309514-150309525 (+)	40,931 bp
Tssr9361	Chr1:150314828-150314855 (+)	46,253 bp
Tssr9362	Chr1:150324576-150324585 (+)	55,992 bp
Tssr9363	Chr1:150324596-150324602 (+)	56,010 bp
Tssr9364	Chr1:150324898-150324929 (+)	56,325 bp