Naa15 MGI Mouse Gene Detail - MGI:1922088 - N(alpha)-acetyltransferase 15, NatA auxiliary subunit

Symbol

Naa15
Name

N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms

5730450D16Rik, ASTBDN, mNAT1, Narg1, Tbdn-1, tubedown

Feature Type

protein coding gene
IDs

MGI:1922088
NCBI Gene: 74838
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:51323437-51383406 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 22.47 cM, cytoband D
Mapping Data

4 experiments

SNPs within 2kb

1217 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922088	protein coding gene	Chr3:51322569-51383928 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027197	protein coding gene	Chr3:49886076-49950273 (+)
A/J	MGP_AJ_G0027157	protein coding gene	Chr3:48428900-48491092 (+)
AKR/J	MGP_AKRJ_G0027126	protein coding gene	Chr3:49395355-49456587 (+)
BALB/cJ	MGP_BALBcJ_G0027169	protein coding gene	Chr3:48289253-48349443 (+)
C3H/HeJ	MGP_C3HHeJ_G0026912	protein coding gene	Chr3:49616488-49682688 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027615	protein coding gene	Chr3:51894851-51957860 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024975	protein coding gene	Chr3:45066761-45119545 (+)
CAST/EiJ	MGP_CASTEiJ_G0026365	protein coding gene	Chr3:49678854-49749884 (+)
CBA/J	MGP_CBAJ_G0026889	protein coding gene	Chr3:53514294-53583426 (+)
DBA/2J	MGP_DBA2J_G0027023	protein coding gene	Chr3:48042340-48099950 (+)
FVB/NJ	MGP_FVBNJ_G0026991	protein coding gene	Chr3:47018720-47082091 (+)
LP/J	MGP_LPJ_G0027135	protein coding gene	Chr3:50639064-50705448 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027009	protein coding gene	Chr3:57705293-57772433 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027674	protein coding gene	Chr3:49311783-49377138 (+)
PWK/PhJ	MGP_PWKPhJ_G0026097	protein coding gene	Chr3:47679099-47751434 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025910	protein coding gene	Chr3:48963223-49034107 (+)
WSB/EiJ	MGP_WSBEiJ_G0026439	protein coding gene	Chr3:49416444-49489127 (+)

Human Ortholog

NAA15, N-alpha-acetyltransferase 15, NatA auxiliary subunit

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAA15, N-alpha-acetyltransferase 15, NatA auxiliary subunit
Synonyms

Ga19, MRD50, NARG1, NAT1P, NATH, TBDN, TBDN100
Links

HGNC:30782

NCBI Gene ID: 80155

neXtProt AC: NX_Q9BXJ9

UniProt: Q9BXJ9
Chr Location

4q31.1; chr4:139301446-139420033 (+) GRCh38

MGI Vertebrate Homology

Naa15 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NAA15
Protein SuperFamily

N-terminal-AcTrfase-A_aux_su
Gene Tree

Naa15

Diseases

1 with human NAA15 associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder 50 IDs autosomal dominant intellectual developmental disorder 50 DOID:0080233 OMIM:617787

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

16 phenotype references

All Mutations and Alleles

43
Endonuclease-mediated

2
Gene trapped

38
Radiation induced

2
Targeted

1
Genomic Mutations

2 involving Naa15
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

69 strains or lines available

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All GO Annotations

24
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

28
cDNA Data

232
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase naa15

ZFIN naa15a, naa15b

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All Sequences

67
RefSeq

2
UniProt

7
CCDS

CCDS17340.1

Ensembl

ENSMUSG00000063273 (Evidence)
NCBI Gene

74838

			Length	Strain/Species	Flank
genomic	74838	NCBI Gene Model \| MGI Sequence Detail	59970	C57BL/6J	± kb
transcript	NM_053089	RefSeq \| MGI Sequence Detail	6090	C57BL/6
polypeptide	Q80UM3	UniProt \| EBI \| MGI Sequence Detail	865	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010989 N-alpha-acetyltransferase 15, NatA auxiliary subunit

(term hierarchy)
InterPro Domains

IPR021183 N-terminal acetyltransferase A, auxiliary subunit

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

IPR013105 Tetratricopeptide repeat 2
GlyGen

Q80UM3 1 site, 1 O-linked glycan (1 site)

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All nucleic 233

cDNA 232

Primer pair 1

Microarray probesets 10

Summaries

All 57

Developmental Gene Expression 9

Diseases 1

Gene Ontology 6

Phenotypes 16
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:308825 Kweon HY, et al., Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway. Elife. 2021 Aug 6;10:e65952

TSS for Naa15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29053	Chr3:51323383-51323394 (+)	-48 bp
Tssr29054	Chr3:51323407-51323465 (+)	-1 bp
Tssr29057	Chr3:51366035-51366051 (+)	42,606 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24