About   Help   FAQ
Usp38 Gene Detail
Summary
  • Symbol
    Usp38
  • Name
    ubiquitin specific peptidase 38
  • Synonyms
    4631402N15Rik, 4833420O05Rik, mKIAA1891
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922091
    NCBI Gene: 74841
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:81707362-81741557 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 38.68 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    818 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922091
 protein coding gene Chr8:81707353-81741631 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033821
 protein coding gene Chr8:81722977-81759084 (-)
A/J MGP_AJ_G0033804
 protein coding gene Chr8:78482159-78515473 (-)
AKR/J MGP_AKRJ_G0033730
 protein coding gene Chr8:80832346-80867181 (-)
BALB/cJ MGP_BALBcJ_G0033797
 protein coding gene Chr8:78585965-78619846 (-)
C3H/HeJ MGP_C3HHeJ_G0033506
 protein coding gene Chr8:81460828-81494115 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034317
 protein coding gene Chr8:84875202-84911034 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031258
 protein coding gene Chr8:72471671-72503966 (-)
CAST/EiJ MGP_CASTEiJ_G0032837
 protein coding gene Chr8:80798112-80833981 (-)
CBA/J MGP_CBAJ_G0033485
 protein coding gene Chr8:87874209-87912023 (-)
DBA/2J MGP_DBA2J_G0033638
 protein coding gene Chr8:78157362-78190494 (-)
FVB/NJ MGP_FVBNJ_G0033583
 protein coding gene Chr8:77105576-77138592 (-)
LP/J MGP_LPJ_G0033728
 protein coding gene Chr8:81808902-81842290 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033626
 protein coding gene Chr8:90353403-90389086 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034334
 protein coding gene Chr8:80830370-80866880 (-)
PWK/PhJ MGP_PWKPhJ_G0032540
 protein coding gene Chr8:77417467-77451495 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032378
 protein coding gene Chr8:79645806-79678226 (-)
WSB/EiJ MGP_WSBEiJ_G0032950
 protein coding gene Chr8:81181535-81216175 (-)



Homology
more
  • Human Ortholog
    USP38, ubiquitin specific peptidase 38
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP38, ubiquitin specific peptidase 38
  • Synonyms
    HP43.8KD
  • Links
    NCBI Gene ID: 84640
    neXtProt AC: NX_Q8NB14
    UniProt: Q8NB14

  • Chr Location
    4q31.21; chr4:143184917-143223874 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to bleomycin-induced inflammation, fibrosis, and lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    46
  • cDNA Data
    110
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038250 Ensembl Gene Model | MGI Sequence Detail 34196 C57BL/6J ±  kb
    transcript ENSMUST00000042724 Ensembl | MGI Sequence Detail 4707 Not Applicable  
    polypeptide ENSMUSP00000039943 Ensembl | MGI Sequence Detail 1042 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017177 ubiquitin carboxyl-terminal hydrolase 38
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR049407 Ubiquitin carboxyl-terminal hydrolase 38-like, N-terminal domain
      IPR050164 Ubiquitin carboxyl-terminal hydrolases
      IPR033840 Ubiquitin-specific peptidase 38
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease domain
    • GlyGen
      Q8BW70 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 112

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918043, MGI:2142429, MGI:2142721, MGI:2142798
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 46
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory