Tmem65 MGI Mouse Gene Detail - MGI:1922118

Symbol

Tmem65
Name

transmembrane protein 65
Synonyms

2610029O13Rik, 4930438D12Rik

Feature Type

protein coding gene
IDs

MGI:1922118
NCBI Gene: 74868
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr15:58654118-58695487 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 25.09 cM
Mapping Data

2 experiments

SNPs within 2kb

1327 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922118	protein coding gene	Chr15:58654118-58695510 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021875	protein coding gene	Chr15:57985813-58027129 (-)
A/J	MGP_AJ_G0021835	protein coding gene	Chr15:55717981-55759495 (-)
AKR/J	MGP_AKRJ_G0021816	protein coding gene	Chr15:57254332-57295596 (-)
BALB/cJ	MGP_BALBcJ_G0021842	protein coding gene	Chr15:55937520-55978866 (-)
C3H/HeJ	MGP_C3HHeJ_G0021616	protein coding gene	Chr15:57380203-57423209 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022281	protein coding gene	Chr15:60234150-60277545 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019818	protein coding gene	Chr15:52804875-52846838 (-)
CAST/EiJ	MGP_CASTEiJ_G0021133	protein coding gene	Chr15:58035274-58079015 (-)
CBA/J	MGP_CBAJ_G0021585	protein coding gene	Chr15:62318239-62359350 (-)
DBA/2J	MGP_DBA2J_G0021709	protein coding gene	Chr15:55631415-55673124 (-)
FVB/NJ	MGP_FVBNJ_G0021687	protein coding gene	Chr15:54677154-54719572 (-)
LP/J	MGP_LPJ_G0021779	protein coding gene	Chr15:57841494-57882796 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021711	protein coding gene	Chr15:67385373-67429613 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022304	protein coding gene	Chr15:57661193-57704047 (-)
PWK/PhJ	MGP_PWKPhJ_G0020878	protein coding gene	Chr15:55630250-55673024 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020715	protein coding gene	Chr15:57458424-57503378 (-)
WSB/EiJ	MGP_WSBEiJ_G0021188	protein coding gene	Chr15:57658866-57700840 (-)

Human Ortholog

TMEM65, transmembrane protein 65

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM65, transmembrane protein 65
Links

HGNC:25203

NCBI Gene ID: 157378

neXtProt AC: NX_Q6PI78

UniProt: Q6PI78
Chr Location

8q24.13; chr8:124306189-124372701 (-) GRCh38

MGI Vertebrate Homology

Tmem65 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM65
Gene Tree

Tmem65

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

3
Endonuclease-mediated

6
Gene trapped

3
Radiation induced

2
Targeted

1
Genomic Mutations

5 involving Tmem65
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

60
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem65

ZFIN tmem65

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All Sequences

46
RefSeq

8
UniProt

2
CCDS

CCDS27493.1

Ensembl

ENSMUSG00000062373 (Evidence)
NCBI Gene

74868

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062373	Ensembl Gene Model \| MGI Sequence Detail	41370	C57BL/6J	± kb
transcript	ENSMUST00000072113	Ensembl \| MGI Sequence Detail	3747	Not Applicable
polypeptide	ENSMUSP00000071984	Ensembl \| MGI Sequence Detail	234	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029815 transmembrane protein 65

(term hierarchy)
InterPro Domains

IPR019537 Transmembrane protein 65

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All nucleic 60

cDNA 60

Microarray probesets 6

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MGI:1913702

Summaries

All 59

Developmental Gene Expression 2

Diseases 1

Gene Ontology 6

Phenotypes 33
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem65:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134409	Chr15:58695480-58695492 (-)	1 bp
Tssr134408	Chr15:58695459-58695470 (-)	22 bp
Tssr134407	Chr15:58695433-58695451 (-)	45 bp
Tssr134406	Chr15:58695415-58695430 (-)	64 bp
Tssr134405	Chr15:58695320-58695331 (-)	161 bp
Tssr134404	Chr15:58695314-58695317 (-)	171 bp
Tssr134403	Chr15:58695256-58695308 (-)	205 bp
Tssr134402	Chr15:58689977-58689982 (-)	5,507 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24