Iqca1 MGI Mouse Gene Detail - MGI:1922168 - IQ motif containing with AAA domain 1

Symbol

Iqca1
Name

IQ motif containing with AAA domain 1
Synonyms

4930465P12Rik, 4930585L22Rik, Iqca

Feature Type

protein coding gene
IDs

MGI:1922168
NCBI Gene: 74918
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:89969854-90081123 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 45.08 cM, cytoband C5
Mapping Data

3 experiments

SNPs within 2kb

2942 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922168	protein coding gene	Chr1:89969854-90081158 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016293	protein coding gene	Chr1:91508066-91625947 (-)
A/J	MGP_AJ_G0016274	protein coding gene	Chr1:88242209-88350525 (-)
AKR/J	MGP_AKRJ_G0016235	protein coding gene	Chr1:90843725-90962286 (-)
BALB/cJ	MGP_BALBcJ_G0016230	protein coding gene	Chr1:88401760-88513006 (-)
C3H/HeJ	MGP_C3HHeJ_G0016059	protein coding gene	Chr1:91059516-91173704 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016689	protein coding gene	Chr1:95054833-95180502 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014407	protein coding gene	Chr1:82521220-82640472 (-)
CAST/EiJ	MGP_CASTEiJ_G0015644	protein coding gene	Chr1:90383818-90500404 (-)
CBA/J	MGP_CBAJ_G0016035	protein coding gene	Chr1:98102355-98221660 (-)
DBA/2J	MGP_DBA2J_G0016138	protein coding gene	Chr1:87469345-87580402 (-)
FVB/NJ	MGP_FVBNJ_G0016137	protein coding gene	Chr1:86484639-86597959 (-)
LP/J	MGP_LPJ_G0016209	protein coding gene	Chr1:92650295-92769928 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016162	protein coding gene	Chr1:101374176-101494455 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016729	protein coding gene	Chr1:90873256-90987706 (-)
PWK/PhJ	MGP_PWKPhJ_G0015428	protein coding gene	Chr1:86862310-86974762 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015211	protein coding gene	Chr1:89782777-89900588 (-)
WSB/EiJ	MGP_WSBEiJ_G0015702	protein coding gene	Chr1:90606595-90722654 (-)

Human Ortholog

IQCA1, IQ motif containing with AAA domain 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IQCA1, IQ motif containing with AAA domain 1
Synonyms

4930465P12Rik, DRC11, IQCA
Links

HGNC:26195

NCBI Gene ID: 79781

neXtProt AC: NX_Q86XH1

UniProt: Q86XH1
Chr Location

2q37.2-q37.3; chr2:236306685-236507535 (-) GRCh38

MGI Vertebrate Homology

Iqca1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IQCA1
Gene Tree

Iqca1

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Genomic Mutations

2 involving Iqca1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice exhibit normal male fertility.

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

3
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

4
UniProt

3
CCDS

CCDS48317.1

Ensembl

ENSMUSG00000026301 (Evidence)
NCBI Gene

74918

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026301	Ensembl Gene Model \| MGI Sequence Detail	111270	C57BL/6J	± kb
transcript	ENSMUST00000212394	Ensembl \| MGI Sequence Detail	2574	Not Applicable
polypeptide	ENSMUSP00000148643	Ensembl \| MGI Sequence Detail	857	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030657 dynein regulatory complex protein 11

(term hierarchy)
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR003959 ATPase, AAA-type, core

IPR052267 Nexin-Dynein Regulatory Complex Component

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 4

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MGI:1923141, MGI:3035497, MGI:7482296

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 8
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Iqca1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12912	Chr1:90081148-90081164 (-)	-33 bp
Tssr12911	Chr1:90081118-90081128 (-)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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