Lrriq1 MGI Mouse Gene Detail - MGI:1922228 - leucine-rich repeats and IQ motif containing 1

Symbol

Lrriq1
Name

leucine-rich repeats and IQ motif containing 1
Synonyms

4930503E15Rik, Gm1557, LOC380658

Feature Type

protein coding gene
IDs

MGI:1922228
NCBI Gene: 74978
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:102881892-103072183 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 53.65 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

5606 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922228	protein coding gene	Chr10:102880238-103072236 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017698	protein coding gene	Chr10:105082027-105286187 (-)
A/J	MGP_AJ_G0017677	protein coding gene	Chr10:101223782-101409495 (-)
AKR/J	MGP_AKRJ_G0017639	protein coding gene	Chr10:104189543-104378947 (-)
BALB/cJ	MGP_BALBcJ_G0017641	protein coding gene	Chr10:101581744-101774013 (-)
C3H/HeJ	MGP_C3HHeJ_G0017466	protein coding gene	Chr10:104202301-104399577 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018098	protein coding gene	Chr10:108757776-108953360 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015777	protein coding gene	Chr10:96468832-96654017 (-)
CAST/EiJ	MGP_CASTEiJ_G0017027	protein coding gene	Chr10:104283485-104490335 (-)
CBA/J	MGP_CBAJ_G0017435	protein coding gene	Chr10:112899550-113124535 (-)
DBA/2J	MGP_DBA2J_G0017540	protein coding gene	Chr10:100321463-100513221 (-)
FVB/NJ	MGP_FVBNJ_G0017534	protein coding gene	Chr10:99398214-99591406 (-)
LP/J	MGP_LPJ_G0017614	protein coding gene	Chr10:105687152-105881310 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017564	protein coding gene	Chr10:114745928-115023347 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018136	protein coding gene	Chr10:104114802-104313599 (-)
PWK/PhJ	MGP_PWKPhJ_G0016809	protein coding gene	Chr10:100432839-100628587 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016599	protein coding gene	Chr10:102940191-103146574 (-)
WSB/EiJ	MGP_WSBEiJ_G0017087	protein coding gene	Chr10:104178182-104398246 (-)

Human Ortholog

LRRIQ1, leucine rich repeats and IQ motif containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRIQ1, leucine rich repeats and IQ motif containing 1
Links

HGNC:25708

NCBI Gene ID: 84125

neXtProt AC: NX_Q96JM4

UniProt: Q96JM4
Chr Location

12q21.31; chr12:85036314-85272805 (+) GRCh38

MGI Vertebrate Homology

Lrriq1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRRIQ1
Gene Tree

Lrriq1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

1
Genomic Mutations

1 involving Lrriq1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

92 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males exhibit reduced male infertility, with reduced sperm motility and increased male germ cell apoptosis.

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrriq1

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All Sequences

70
RefSeq

35
UniProt

3
CCDS

CCDS48686.1, CCDS48687.1

Ensembl

ENSMUSG00000019892 (Evidence)
NCBI Gene

74978

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019892	Ensembl Gene Model \| MGI Sequence Detail	190292	C57BL/6J	± kb
transcript	ENSMUST00000166240	Ensembl \| MGI Sequence Detail	5232	Not Applicable
polypeptide	ENSMUSP00000131419	Ensembl \| MGI Sequence Detail	1673	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032607 leucine-rich repeat and IQ domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR050576 Ciliary and flagellar integrity-associated protein

IPR000048 IQ motif, EF-hand binding site

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR050836 SDS22/Internalin LRR-containing
GlyGen

Q0P5X1 1 site, 1 O-linked glycan (1 site)

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All nucleic 8

cDNA 8

Microarray probesets 1

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MGI:2686403

Summaries

All 30

Gene Ontology 1

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:338085 Fukutomi M, et al., Lrriq1 is an essential factor for fertility by suppressing apoptosis. J Assist Reprod Genet. 2022 Nov;39(11):2647-2657

TSS for Lrriq1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99158	Chr10:103072206-103072215 (-)	-28 bp
Tssr99157	Chr10:103072141-103072188 (-)	18 bp
Tssr99156	Chr10:102981338-102981353 (-)	90,837 bp
Tssr99155	Chr10:102980829-102980840 (-)	91,348 bp
Tssr99154	Chr10:102980782-102980791 (-)	91,396 bp
Tssr99153	Chr10:102882163-102882166 (-)	190,018 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24