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Usp47 Gene Detail
Summary
  • Symbol
    Usp47
  • Name
    ubiquitin specific peptidase 47
  • Synonyms
    4930502N04Rik, A630020C16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922246
    NCBI Gene: 74996
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:111622692-111710591 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 58.74 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1427 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922246
 protein coding gene Chr7:111622692-111710868 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032866
 protein coding gene Chr7:115564351-115666058 (+)
A/J MGP_AJ_G0032849
 protein coding gene Chr7:112700518-112789915 (+)
AKR/J MGP_AKRJ_G0032781
 protein coding gene Chr7:115536357-115624446 (+)
BALB/cJ MGP_BALBcJ_G0032854
 protein coding gene Chr7:112380667-112468414 (+)
C3H/HeJ MGP_C3HHeJ_G0032564
 protein coding gene Chr7:115518024-115617962 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033360
 protein coding gene Chr7:120305310-120403536 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030332
 protein coding gene Chr7:114300825-114390322 (+)
CAST/EiJ MGP_CASTEiJ_G0031892
 protein coding gene Chr7:107134767-107226517 (+)
CBA/J MGP_CBAJ_G0032537
 protein coding gene Chr7:124258783-124354960 (+)
DBA/2J MGP_DBA2J_G0032689
 protein coding gene Chr7:110785891-110875453 (+)
FVB/NJ MGP_FVBNJ_G0032642
 protein coding gene Chr7:110632072-110722460 (+)
LP/J MGP_LPJ_G0032783
 protein coding gene Chr7:117082077-117174020 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032674
 protein coding gene Chr7:125863360-125969638 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033380
 protein coding gene Chr7:114537217-114630383 (+)
PWK/PhJ MGP_PWKPhJ_G0031599
 protein coding gene Chr7:103623558-103712348 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031447
 protein coding gene Chr7:101286749-101381998 (+)
WSB/EiJ MGP_WSBEiJ_G0032005
 protein coding gene Chr7:115398280-115489720 (+)



Homology
more
  • Human Ortholog
    USP47, ubiquitin specific peptidase 47
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP47, ubiquitin specific peptidase 47
  • Synonyms
    TRFP
  • Links
    NCBI Gene ID: 55031
    neXtProt AC: NX_Q96K76
    UniProt: Q96K76

  • Chr Location
    11p15.3; chr11:11841423-11961887 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mouse embryonic fibroblasts from mice homozygous for a gene trap allele exhibit increased sensitivity to UV irradiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74996 NCBI Gene Model | MGI Sequence Detail 87900 C57BL/6J ±  kb
    transcript NM_001403494 RefSeq | MGI Sequence Detail 5679 C57BL/6  
    polypeptide Q8BY87 UniProt | EBI | MGI Sequence Detail 1376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000017186 ubiquitin carboxyl-terminal hydrolase 47
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR045578 Ubiquitin carboxyl-terminal hydrolase 47, C-terminal
      IPR050164 Ubiquitin carboxyl-terminal hydrolases
      IPR029071 Ubiquitin-like domain superfamily
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease domain
    • GlyGen
      Q8BY87 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2444648
    References
    more
    • Summaries
      All 54
      Gene Ontology 6
      Phenotypes 27
    • Earliest
      J:61682 Hagiwara N, et al., Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4180-5
    • Latest
      J:353390 Wang QL, et al., USP47 deficiency in mice modulates tumor infiltrating immune cells and enhances antitumor immune responses in prostate cancer. Cancer Immunol Immunother. 2024 Jun 4;73(8):143
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory