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Lrrc8d Gene Detail
Summary
  • Symbol
    Lrrc8d
  • Name
    leucine rich repeat containing 8D
  • Synonyms
    2810473G09Rik, 4930525N13Rik, Lrrc5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922368
    NCBI Gene: 231549
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:105847829-105963081 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3498 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922368
 protein coding gene Chr5:105847829-105980302 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029827
 protein coding gene Chr5:107604420-107748501 (+)
A/J MGP_AJ_G0029791
 protein coding gene Chr5:103507703-103639020 (+)
AKR/J MGP_AKRJ_G0029736
 protein coding gene Chr5:106876296-107013073 (+)
BALB/cJ MGP_BALBcJ_G0029803
 protein coding gene Chr5:104653544-104787662 (+)
C3H/HeJ MGP_C3HHeJ_G0029525
 protein coding gene Chr5:107293605-107432030 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030257
 protein coding gene Chr5:112079904-112223203 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027492
 protein coding gene Chr5:98609880-98739308 (+)
CAST/EiJ MGP_CASTEiJ_G0028939
 protein coding gene Chr5:106183252-106323126 (+)
CBA/J MGP_CBAJ_G0029493
 protein coding gene Chr5:115832038-115973747 (+)
DBA/2J MGP_DBA2J_G0029639
 protein coding gene Chr5:103669711-103799996 (+)
FVB/NJ MGP_FVBNJ_G0029596
 protein coding gene Chr5:102386617-102516286 (+)
LP/J MGP_LPJ_G0029727
 protein coding gene Chr5:108210142-108346855 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029628
 protein coding gene Chr5:120863322-121001700 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030291
 protein coding gene Chr5:106395022-106533855 (+)
PWK/PhJ MGP_PWKPhJ_G0028652
 protein coding gene Chr5:102440143-102568975 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028490
 protein coding gene Chr5:103903150-104057560 (+)
WSB/EiJ MGP_WSBEiJ_G0029012
 protein coding gene Chr5:106722235-106857196 (+)



Homology
more
  • Human Ortholog
    LRRC8D, leucine rich repeat containing 8 VRAC subunit D
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC8D, leucine rich repeat containing 8 VRAC subunit D
  • Synonyms
    HsLRRC8D, LRRC5
  • Links
    NCBI Gene ID: 55144
    neXtProt AC: NX_Q7L1W4
    UniProt: Q7L1W4

  • Chr Location
    1p22.2; chr1:89821014-89936611 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal response to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    18
  • cDNA Data
    14
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231549 NCBI Gene Model | MGI Sequence Detail 115253 C57BL/6J ±  kb
    transcript NM_001122768 RefSeq | MGI Sequence Detail 3944 C57BL/6  
    polypeptide Q8BGR2 UniProt | EBI | MGI Sequence Detail 859 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920077
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 24
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory